Okay, so I am making some progress.
CAT is wired and working, and RX audio from the radio is getting to the computer and being decoded. I am still not getting any TX tones from the computer into the radio through the DATA jack. The radio keys, but this could be CAT doing that. The computer is putting out the tones, because if I direct the audio to my speakers I hear it just fine.
I'm at a loss.