The configuration data may be corrupted. Completely uninstalling the program then reinstalling might help if no one has a better option. I'm running Fedora 40 as well, using the program installed with dnf. I couldn't find where the configuration data is stored to see if there is any way to clear it. As someone noted, when installed the filters bits should be set properly by default.??
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In the "Bands" tab there is a Tx IO label on the right side, with an enable check box underneath it. Normally the codes in the RX filter are used for TX as well and the TX IO bits are all blank but this enables different filters on transmit and receive. I doubt that's the problem with your setup as I can click on a bit to set it and click again to clear it on the boxes in both filter banks regardless of the check box setting. If you can't select bits on either filter bank, corrupted software or a permissions problem is likely the issue.?
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73, Doug AH6DL