As MGmail says, it depends on what the form-factor is.
Either way, you should look at . they have integration devices for Mitsu and other Mini-Split systems. I only deal with Custom/SMW systems, but I'm sure that they are working in CH as well...
If this is an actual "standard Mini-Split" with a wall/ceiling mount head unit (the standard old-school, ugly wall unit type), CoolAuto will work without any additional Mitsu stuff.
If it is a "Ducted Mini-Split" where you have 'traditional' air ducts, etc. this format will require a temp sensor, etc.
>>> I just resolved an issue with a Mitsu Ducted unit and the best solution was to use one of Mitsu's TStats with thier remote temp sensor, then we used the CoolAuto unit to integrate with Crestron...
>>> There is also a way to use a 'Standard' TStat like a CHV or Horizon unit with the ducted style, but you'll need an appropriate Mitsu interface module (You'll have to research that one...)