SECOND INCIDENT AGE? - never COMPROMISED DISC CUP RATIO?– Yes UNAFFECTED EYE - no problem USING OZEMPIC OR SIMILAR NO - No POSSIBLE NOCTURNAL HYPOTENSION - unknown? CAUSAL RELATIONSHIP TO COVID ILLNESS MAYBE - No CAUSAL RELATIONSHIP TO COVID VACCINE MAYBE - No
Tim THIS WILL BE AN INVALUABLE SURVEY On Mon, 17 Mar 2025 at 05:29, George Ousler via <sailfishin=[email protected]> wrote: Thanks for your post. I feel obligated to let you know that I was in your shoes not too long ago (March 2024) and unfortunately suffered from a second NAION in my neighboring eye after using a GLP (Mounjorno) for approximately 6 months. I completely understand the risk vs. benefit ratio and that the improvements from weight loss, etc. are tremendous but I have to say that the potential loss of vision in both eyes is devastating. Once you have a NAION in both eyes, there may be significant blind spots based on the areas between your two eyes that overlap and therefore have true total vision loss (when there is only one eye involved, the neighboring eye compensates to the point where you don't notice the vision loss). I'm not suggesting that you change your opinion / plan, rather, just be sure that you can't control your diabetes, etc. through diet, other medications, etc. to try to prevent an ischemic event from GLP induced decreased blood flow. Also, do you have crowded disc syndrome (small cup to disc ratio in both eyes)? As you know, once it occurs, you can't reverse it. I've been seeing a neuro-ophthalmologist at Mass Eye and Eye who has been researching and publishing on the association between NAION and GLPs. Please google Dr. Rizzo at Mass General Hospitals and NAION to learn more. Happy to discuss more Marc (and anyone else in this group) to share my experience - once you have a second NAION, the game changes significantly. Thanks. On Sunday, March 16, 2025 at 10:57:23 PM EDT, Marc Gold via <marcgold=[email protected]> wrote: The evidence of a link between Semaglutide and NAION is indeed very weak. I already have NAION in one eye.?
The improvement of my diabetes, weight, heart and kidney status worries me far more than the small chance my other eye could be affected by Ozempic.
I start Ozempic next week @ 1 mg. per week. My physician concurs that the benefits far outweigh the risks. I'll take my chances, which are not high at all:
Even though we have demonstrated a higher risk of NAION in persons with T2D exposed to once-weekly semaglutide, it is important to keep in mind that use of semaglutide comes with substantial advantages for patients as given by the improved glycemic control, reduction in risk of cardiovascular disease as well as the beneficial effects of weight loss [1]. As such, the observed incidence rate of NAION of 0·228 per 1000 person-years for persons with T2D exposed with once-weekly semaglutide may not discourage semaglutide treatment but needs to be acknowledged as a potential risk.
This is truly a miracle drug in the same way that penicillin, statin drugs, Covid vaccines, insulin and Sildenafil have demonstrated. We are lucky to live in this age of pharmaceutical advances and wonders. I will report my progress which should allay some of your concerns about?Semaglutide and NAION.
|
On Monday, March 17, 2025 at 05:32:20 PM CDT, David Cattle via groups.io <djacattle@...> wrote:
SECOND INCIDENT AGE? - never COMPROMISED DISC CUP RATIO?– don't know UNAFFECTED EYE - no problem USING OZEMPIC OR SIMILAR NO - No POSSIBLE NOCTURNAL HYPOTENSION - possible CAUSAL RELATIONSHIP TO COVID ILLNESS MAYBE - No CAUSAL RELATIONSHIP TO COVID VACCINE MAYBE - No OTHER?– have been taking lipid chloresterol medication for two years? ? William THIS WILL BE AN INVALUABLE SURVEY
On Mon, 17 Mar 2025 at 05:29, George Ousler via <sailfishin= [email protected]> wrote: Thanks for your post. I feel obligated to let you know that I was in your shoes not too long ago (March 2024) and unfortunately suffered from a second NAION in my neighboring eye after using a GLP (Mounjorno) for approximately 6 months. I completely understand the risk vs. benefit ratio and that the improvements from weight loss, etc. are tremendous but I have to say that the potential loss of vision in both eyes is devastating. Once you have a NAION in both eyes, there may be significant blind spots based on the areas between your two eyes that overlap and therefore have true total vision loss (when there is only one eye involved, the neighboring eye compensates to the point where you don't notice the vision loss). I'm not suggesting that you change your opinion / plan, rather, just be sure that you can't control your diabetes, etc. through diet, other medications, etc. to try to prevent an ischemic event from GLP induced decreased blood flow. Also, do you have crowded disc syndrome (small cup to disc ratio in both eyes)? As you know, once it occurs, you can't reverse it. I've been seeing a neuro-ophthalmologist at Mass Eye and Eye who has been researching and publishing on the association between NAION and GLPs. Please google Dr. Rizzo at Mass General Hospitals and NAION to learn more. Happy to discuss more Marc (and anyone else in this group) to share my experience - once you have a second NAION, the game changes significantly. Thanks. On Sunday, March 16, 2025 at 10:57:23 PM EDT, Marc Gold via <marcgold=[email protected]> wrote: The evidence of a link between Semaglutide and NAION is indeed very weak. I already have NAION in one eye.?
The improvement of my diabetes, weight, heart and kidney status worries me far more than the small chance my other eye could be affected by Ozempic.
I start Ozempic next week @ 1 mg. per week. My physician concurs that the benefits far outweigh the risks. I'll take my chances, which are not high at all:
Even though we have demonstrated a higher risk of NAION in persons with T2D exposed to once-weekly semaglutide, it is important to keep in mind that use of semaglutide comes with substantial advantages for patients as given by the improved glycemic control, reduction in risk of cardiovascular disease as well as the beneficial effects of weight loss [1]. As such, the observed incidence rate of NAION of 0·228 per 1000 person-years for persons with T2D exposed with once-weekly semaglutide may not discourage semaglutide treatment but needs to be acknowledged as a potential risk.
This is truly a miracle drug in the same way that penicillin, statin drugs, Covid vaccines, insulin and Sildenafil have demonstrated. We are lucky to live in this age of pharmaceutical advances and wonders. I will report my progress which should allay some of your concerns about?Semaglutide and NAION.
|
FIRST INCIDENT AGE 62 - 57 SECOND INCIDENT AGE ?N/A - 65 COMPROMISED DISC CUP RATIO?– N/A AFFECTED EYE YES – Yes both USING OZEMPIC OR SIMILAR NO - No POSSIBLE NOCTURNAL HYPOTENSION - Yes CAUSAL RELATIONSHIP TO COVID ILLNESS MAYBE - No CAUSAL RELATIONSHIP TO COVID VACCINE MAYBE - No OTHER?– Leiden Factor V, previously heavy alcohol use, ? David THIS WILL BE AN INVALUABLE SURVEY
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On Mon, 17 Mar 2025 at 05:29, George Ousler via <sailfishin= [email protected]> wrote: Thanks for your post. I feel obligated to let you know that I was in your shoes not too long ago (March 2024) and unfortunately suffered from a second NAION in my neighboring eye after using a GLP (Mounjorno) for approximately 6 months. I completely understand the risk vs. benefit ratio and that the improvements from weight loss, etc. are tremendous but I have to say that the potential loss of vision in both eyes is devastating. Once you have a NAION in both eyes, there may be significant blind spots based on the areas between your two eyes that overlap and therefore have true total vision loss (when there is only one eye involved, the neighboring eye compensates to the point where you don't notice the vision loss). I'm not suggesting that you change your opinion / plan, rather, just be sure that you can't control your diabetes, etc. through diet, other medications, etc. to try to prevent an ischemic event from GLP induced decreased blood flow. Also, do you have crowded disc syndrome (small cup to disc ratio in both eyes)? As you know, once it occurs, you can't reverse it. I've been seeing a neuro-ophthalmologist at Mass Eye and Eye who has been researching and publishing on the association between NAION and GLPs. Please google Dr. Rizzo at Mass General Hospitals and NAION to learn more. Happy to discuss more Marc (and anyone else in this group) to share my experience - once you have a second NAION, the game changes significantly. Thanks. On Sunday, March 16, 2025 at 10:57:23 PM EDT, Marc Gold via <marcgold=[email protected]> wrote: The evidence of a link between Semaglutide and NAION is indeed very weak. I already have NAION in one eye.?
The improvement of my diabetes, weight, heart and kidney status worries me far more than the small chance my other eye could be affected by Ozempic.
I start Ozempic next week @ 1 mg. per week. My physician concurs that the benefits far outweigh the risks. I'll take my chances, which are not high at all:
Even though we have demonstrated a higher risk of NAION in persons with T2D exposed to once-weekly semaglutide, it is important to keep in mind that use of semaglutide comes with substantial advantages for patients as given by the improved glycemic control, reduction in risk of cardiovascular disease as well as the beneficial effects of weight loss [1]. As such, the observed incidence rate of NAION of 0·228 per 1000 person-years for persons with T2D exposed with once-weekly semaglutide may not discourage semaglutide treatment but needs to be acknowledged as a potential risk.
This is truly a miracle drug in the same way that penicillin, statin drugs, Covid vaccines, insulin and Sildenafil have demonstrated. We are lucky to live in this age of pharmaceutical advances and wonders. I will report my progress which should allay some of your concerns about?Semaglutide and NAION.
|
George,
Just curious, what was your dose of Monjourno? I am on a the lowest dose of Ozempic .25 mg and lost my left eye vision with a NAION attack 5 years ago. My NO at Cornell says that my other eye does not have a low cup to disc. My attack was probably caused by low BP drop from another disease that was untreated at the time called AVP-D Deficiency. My blood pressure is usually always low. Any help you can give me with this would be much appreciated.
On Sun, Feb 16, 2025 at 10:36?PM George Ousler via <sailfishin= [email protected]> wrote:
Hi There,
I have had a NAION in both eyes. First happened in my right?eye at age 41 and then the left eye just a few months ago at age 49. I have small cup?to disc ratio on both eyes (crowded disc syndrome from birth). The first occurrence happened after starting a low dose of BP meds that I provably didn’t need. I was taking it at night which was incorrect. My BP dropped lower than it should have between the medication and diurnal (evening lowering) changes. I lost about 35% of my vision in the lower inferior visual field (6 to 9 o'clock). Then I most recently lost vision inferiority (3 to 6 o’clock) in my left eye after taking monjourno (GLP2 similar to ozempic) for about 6 months. My neuro ophthalmologist out of mass eye and ear?in Boston is convinced it is due to monjourno - he published his resesrch?on the topic. I also work in research for ophthalmology and I’m happy to explain more as needed. But the use of steroids for a NAION is not well supported. It is usually used as a last ditch effort for those who have serious vision loss in both eyes. However there are few studies that show it does anything helpful. If you are a diabetic and have high BP it may not be worth the side efforts of steroids. Long story short the use of steroids have not helped but if you don’t have diabetes or high BP there is no risk of trying steroids. They need to be at high doses early after the NAION.??I will say that the GLP2 are very dangerous for those of us who have had NAIONs. Do not use these?drugs!!! Please let me know if I can help. George?
On Sunday, February 16, 2025, 9:57 PM, aowats3 via <aowats3=[email protected]> wrote: How prevalent is steroid treatment after NAAION diagnosis? I’ve had NAAION one month max, in one eye, triggered, I believe, by Ozempic, which I’ve obviously stopped. Just had tests for carotid arteries, electrocardiogram and brain MRI without contrast, all negative. Have sleep apnea and type 2 dm, both well controlled. 79 years old.
-- DEBRA BROWN-GROSSMAN, MPH, RDNPediatric and Adolescent Nutrition Specialist Adult Nutrition and Weight Management Consultant 518-888-2929? ?fax: 518-751-2403
|
?
The two hardest tests on the spiritual road are the patience to wait for the right moment and the courage not to be disappointed with what we encounter----Paulo Coelho?
I would be true, for there are those who trust me: I would be pure, for there are those who care; I would be strong, for there is much to suffer; I would be brave, for there is much to dare-Howard Walter
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On 03/17/2025 10:17 AM EDT Andrew Watson via groups.io <aowats3@...> wrote:
?
?
SEX MALE
?
FIRST INCIDENT AGE 57
?
CURRENT AGE 60
?
SECOND INCIDENT AGE ?N/A
?
COMPROMISED DISC CUP RATIO?
?
AFFECTED EYE yes
?
UNAFFECTED EYE YES
?
USING OZEMPIC OR SIMILAR no
?
HYPERTENSION no
?
POSSIBLE NOCTURNAL HYPOTENSION PERHAPS
?
DIABETES slightly elevated--just above 100
?
SLEEP APNOEA no
?
CAUSAL RELATIONSHIP TO COVID ILLNESS possibly
?
CAUSAL RELATIONSHIP TO COVID VACCINE NO
?
STILL DRIVING YES, but not at night
?
OTHER: high cholestrol
|
SEX - Female
1st incident - 65
Current age - 67
Second incident - N/A
Compromised disc - edema at disc
Affected eye - Yes - left eye
Unaffected eye - Yes
Ozempic - No .? Diabetic but on Metformin and Lantus
HTN - No
Poss Noct Hypotension - ?
Sleep apnea - yes
Causal Covid illness - No
Causal Covid vaccine - Not sure
Driving - Yes, but only during the day
Other - Diabetic x 20 yrs, sugars well controlled, not using a CPAP machine.? Plan to revisit and assess sleep apnea
On Mon, Mar 17, 2025, 10:17?a.m. Andrew Watson via <aowats3= [email protected]> wrote: SEX MALE ? FIRST INCIDENT AGE 78 (8 wks ago) ? CURRENT AGE 78 ? SECOND INCIDENT AGE ?N/A ? COMPROMISED DISC CUP RATIO? ? AFFECTED EYE UNK ? UNAFFECTED EYE YES ? USING OZEMPIC OR SIMILAR YES ? HYPERTENSION MILD ? POSSIBLE NOCTURNAL HYPOTENSION PERHAPS ? DIABETES YES ? SLEEP APNOEA YES, well controlled ? CAUSAL RELATIONSHIP TO COVID ILLNESS NO ? CAUSAL RELATIONSHIP TO COVID VACCINE NO ? STILL DRIVING YES ? OTHER: just slightly obese; history of AFIB; had an isolated AFib incident with tachycardia around time stricken
|
SEX MALE ? FIRST INCIDENT AGE 78 (8 wks ago) ? CURRENT AGE 78 ? SECOND INCIDENT AGE ?N/A ? COMPROMISED DISC CUP RATIO? ? AFFECTED EYE UNK ? UNAFFECTED EYE YES ? USING OZEMPIC OR SIMILAR YES ? HYPERTENSION MILD ? POSSIBLE NOCTURNAL HYPOTENSION PERHAPS ? DIABETES YES ? SLEEP APNOEA YES, well controlled ? CAUSAL RELATIONSHIP TO COVID ILLNESS NO ? CAUSAL RELATIONSHIP TO COVID VACCINE NO ? STILL DRIVING YES ? OTHER: just slightly obese; history of AFIB; had an isolated AFib incident with tachycardia around time stricken
|
SEX female
FIRST INCIDENT AGE 58
CURRENT AGE 63
SECOND INCIDENT AGE ?N/A
COMPROMISED DISC CUP RATIO
AFFECTED EYE YES, no acuity
UNAFFECTED EYE YES
USING OZEMPIC OR SIMILAR NO
HYPERTENSION NO
POSSIBLE NOCTURNAL HYPOTENSION NO
DIABETES NO
SLEEP APNOEA NO
CAUSAL RELATIONSHIP TO COVID ILLNESS NO
CAUSAL RELATIONSHIP TO COVID VACCINE NO
STILL DRIVING During the day
OTHER - small cup/disc both eyes
SEX MALE
?
FIRST INCIDENT AGE 65
?
CURRENT AGE 68
?
SECOND INCIDENT AGE ?N/A
?
COMPROMISED DISC CUP RATIO?
?
AFFECTED EYE YES
?
UNAFFECTED EYE YES
?
USING OZEMPIC OR SIMILAR NO
?
HYPERTENSION YES
?
POSSIBLE NOCTURNAL HYPOTENSION NO
?
DIABETES NO
?
SLEEP APNOEA Mild 12 AHI now corrected by HGNS
?
CAUSAL RELATIONSHIP TO COVID ILLNESS NO
?
CAUSAL RELATIONSHIP TO COVID VACCINE NO
?
STILL DRIVING YES
?
OTHER: Suspicious of virus/antibody causal relationship?
|
Thanks to all who have responded.?
Cone on all fellow members, let’s hear your feedback.?
So valuable to hear all of this
Terry
SEX MALE
?
FIRST INCIDENT AGE 65
?
CURRENT AGE 68
?
SECOND INCIDENT AGE ?N/A
?
COMPROMISED DISC CUP RATIO?
?
AFFECTED EYE YES
?
UNAFFECTED EYE YES
?
USING OZEMPIC OR SIMILAR NO
?
HYPERTENSION YES
?
POSSIBLE NOCTURNAL HYPOTENSION NO
?
DIABETES NO
?
SLEEP APNOEA Mild 12 AHI now corrected by HGNS
?
CAUSAL RELATIONSHIP TO COVID ILLNESS NO
?
CAUSAL RELATIONSHIP TO COVID VACCINE NO
?
STILL DRIVING YES
?
OTHER: Suspicious of virus/antibody causal relationship?
|
SEX MALE
?
FIRST INCIDENT AGE 65
?
CURRENT AGE 68
?
SECOND INCIDENT AGE ?N/A
?
COMPROMISED DISC CUP RATIO?
?
AFFECTED EYE YES
?
UNAFFECTED EYE YES
?
USING OZEMPIC OR SIMILAR NO
?
HYPERTENSION YES
?
POSSIBLE NOCTURNAL HYPOTENSION NO
?
DIABETES NO
?
SLEEP APNOEA Mild 12 AHI now corrected by HGNS
?
CAUSAL RELATIONSHIP TO COVID ILLNESS NO
?
CAUSAL RELATIONSHIP TO COVID VACCINE NO
?
STILL DRIVING YES
?
OTHER: Suspicious of virus/antibody causal relationship?
|
SEX Female
FIRST INCIDENT AGE 41
CURRENT AGE 61
SECOND INCIDENT AGE 61 - occurred 4 weeks ago
COMPROMISED DISC CUP RATIO yes
AFFECTED EYE yes
UNAFFECTED EYE Both are affected
USING OZEMPIC OR SIMILAR NO
HYPERTENSION No
POSSIBLE NOCTURNAL HYPOTENSION No
DIABETES NO
SLEEP APNOEA NO
CAUSAL RELATIONSHIP TO COVID ILLNESS No,
CAUSAL RELATIONSHIP TO COVID VACCINE No
STILL DRIVING YES, in my small town
OTHER
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On Mar 16, 2025, at 11:59?PM, Terry Berelowitz via groups.io <craigberelowitz@...> wrote:
SEX MALE
FIRST INCIDENT AGE 62
CURRENT AGE 66
SECOND INCIDENT AGE N/A
COMPROMISED DISC CUP RATIO
AFFECTED EYE YES
UNAFFECTED EYE YES
USING OZEMPIC OR SIMILAR NO
HYPERTENSION YES
POSSIBLE NOCTURNAL HYPOTENSION
DIABETES NO
SLEEP APNOEA NO
CAUSAL RELATIONSHIP TO COVID ILLNESS MAYBE
CAUSAL RELATIONSHIP TO COVID VACCINE MAYBE
STILL DRIVING YES
OTHER
|
NAION SURVEY
Sex - Female
First incident age -65
Current age -65
Second incident age -N/A
Affected eye ~ left eye
Affected Eye - yes
Unaffected eye - yes
Using Ozempic or similar- no
Hypertension - yes controlled by meds over 30 years
Possible nocturnal hypotension- yes
Diabetes ~ no
Sleep apnea - not yet tested but don’t think so
Causal relationship to COVID illness- no
Causal relationship to COVID vaccine - no
Still driving - yes in daylight
Other - we have retirement travel plans to some places with high altitude, would you guys cancel ? My incident happened at 465 ft above sea level. How do you cope with the worry of second eye involvement. My incident occurred at the end of January.
|
Hi
This survey sounds like a good idea.? Here are my responses: -
SEX female
FIRST INCIDENT - AGE 66
CURRENT AGE -? 67
SECOND INCIDENT AGE -? ?N/A
AFFECTED EYE - LEFT EYE
UNAFFECTED EYE - RIGHT EYE, SHOWS DAMAGE ON MRI SCAN BUT VISION OKAY
USING OZEMPIC OR SIMILAR - NO
HYPERTENSION - YES AT TIME OF NAION ATTACK BUT NOT NOW
POSSIBLE NOCTURNAL HYPOTENSION - YES
DIABETES -? NO
SLEEP APNOEA - NO
CAUSAL RELATIONSHIP TO COVID ILLNESS - NO
CAUSAL RELATIONSHIP TO COVID VACCINE - NO
STILL DRIVING - YES (SHORT DISTANCES ONLY, MAX 30 MINS)?
OTHER? -? TESTS FOLLOWING NAION FOUND I HAD SEVERAL VASCULAR ISSUES;? HIGH CHOLESTEROL, HIGH SUGAR & SODIUM, MILD ARRYTHMIA & SLIGHTLY OVERWEIGHT.? THESE NOW MOSTLY UNDER CONTROL.? TAKING A LOW DOSE STATIN AND MINI ASPIRIN DAILY.? NOW DRINKING MORE WATER AND
WALKING 5 MILES DAILY.
On Mon, 17 Mar 2025 at 3:59?pm, Terry Berelowitz via ?<craigberelowitz= [email protected]> wrote:
HULLO ALL
FEAR OF NAION AFFECTING OUR HEALTHY EYE LIVES WITH ALL OF US
WE LOOK AT THE STATS FOR REASSURANCE
IT WOULD BE SO HELPFUL, I’M SURE TO ALL TO HAVE A QUICK SURVEY IN OUR GROUP
PKEASE DO ANSWER SO THAT WE CAN APPRECIATE THE REAL PICTURE
I’LL START
SEX MALE
FIRST INCIDENT AGE 62
CURRENT AGE 66
SECOND INCIDENT AGE ?N/A
COMPROMISED DISC CUP RATIO?
AFFECTED EYE YES
UNAFFECTED EYE YES
USING OZEMPIC OR SIMILAR NO
HYPERTENSION YES
POSSIBLE NOCTURNAL HYPOTENSION
DIABETES NO
SLEEP APNOEA NO
CAUSAL RELATIONSHIP TO COVID ILLNESS MAYBE
CAUSAL RELATIONSHIP TO COVID VACCINE MAYBE
STILL DRIVING YES
OTHER?
THIS WILL BE AN INVALUABLE SURVEY
From:[email protected] on behalf of Chiarina Blake via groups.io
Sent:?Monday, March 17, 2025 05:45
To:[email protected]
Subject:?Re: [NAION] SURVEY
I’LL START
SEX female
FIRST INCIDENT AGE 58
CURRENT AGE 64
SECOND INCIDENT AGE ?N/A
AFFECTED EYE YES
UNAFFECTED EYE YES
USING OZEMPIC OR SIMILAR NO
HYPERTENSION No
POSSIBLE NOCTURNAL HYPOTENSION yes
DIABETES NO
SLEEP APNOEA Yes
CAUSAL RELATIONSHIP TO COVID ILLNESS No
CAUSAL RELATIONSHIP TO COVID VACCINE No
STILL DRIVING No
OTHER?
NAION affected my only good functioning eye. I was born with an under developed retina in my other eye. Confirmed cause of my attack was Sleep Apnea
On Mon, 17 Mar 2025 at 3:59?pm, Terry Berelowitz via
?<craigberelowitz= [email protected]> wrote:
HULLO ALL
FEAR OF NAION AFFECTING OUR HEALTHY EYE LIVES WITH ALL OF US
WE LOOK AT THE STATS FOR REASSURANCE
IT WOULD BE SO HELPFUL, I’M SURE TO ALL TO HAVE A QUICK SURVEY IN OUR GROUP
PKEASE DO ANSWER SO THAT WE CAN APPRECIATE THE REAL PICTURE
I’LL START
SEX MALE
FIRST INCIDENT AGE 62
CURRENT AGE 66
SECOND INCIDENT AGE ?N/A
COMPROMISED DISC CUP RATIO?
AFFECTED EYE YES
UNAFFECTED EYE YES
USING OZEMPIC OR SIMILAR NO
HYPERTENSION YES
POSSIBLE NOCTURNAL HYPOTENSION
DIABETES NO
SLEEP APNOEA NO
CAUSAL RELATIONSHIP TO COVID ILLNESS MAYBE
CAUSAL RELATIONSHIP TO COVID VACCINE MAYBE
STILL DRIVING YES
OTHER?
THIS WILL BE AN INVALUABLE SURVEY
PLEASE DO ANSWER
THANK YOU
TERRY
MEDICAL SPECIALIST
On Mon, 17 Mar 2025 at 05:29, George Ousler via ?<sailfishin= [email protected]> wrote:
Hi Marc,
Thanks for your post. I feel obligated to let you know that I was in your shoes not too long ago (March 2024) and unfortunately suffered from a second NAION in my neighboring eye after using a GLP (Mounjorno) for approximately 6
months. I completely understand the risk vs. benefit ratio and that the improvements from weight loss, etc. are tremendous but I have to say that the potential loss of vision in both eyes is devastating. Once you have a NAION in both eyes, there may be significant
blind spots based on the areas between your two eyes that overlap and therefore have true total vision loss (when there is only one eye involved, the neighboring eye compensates to the point where you don't notice the vision loss). I'm not suggesting that
you change your opinion / plan, rather, just be sure that you can't control your diabetes, etc. through diet, other medications, etc. to try to prevent an ischemic event from GLP induced decreased blood flow. Also, do you have crowded disc syndrome (small
cup to disc ratio in both eyes)? As you know, once it occurs, you can't reverse it. I've been seeing a neuro-ophthalmologist at Mass Eye and Eye who has been researching and publishing on the association between NAION and GLPs. Please google Dr. Rizzo at Mass
General Hospitals and NAION to learn more. Happy to discuss more Marc (and anyone else in this group) to share my experience - once you have a second NAION, the game changes significantly. Thanks.
George ?
On Sunday, March 16, 2025 at 10:57:23 PM EDT, Marc Gold via ?<marcgold= [email protected]> wrote:
The evidence of a link between Semaglutide and NAION is indeed very weak. I already have NAION in one eye.?
The improvement of my diabetes, weight, heart and kidney status worries me far more than the small chance my other eye could be affected by Ozempic.
I start Ozempic next week @ 1 mg. per week. My physician concurs that the benefits far outweigh the risks. I'll take my chances, which are not high at all:
Even though we have demonstrated a higher risk of NAION in persons with T2D exposed to once-weekly semaglutide,
it is important to keep in mind that use of semaglutide comes with substantial advantages for patients as given by the improved glycemic control, reduction in risk of cardiovascular disease as well as the beneficial effects of weight loss [1]. As such, the
observed incidence rate of NAION of 0·228 per 1000 person-years for persons with T2D exposed with once-weekly semaglutide may not discourage semaglutide treatment but needs to be acknowledged as a potential risk.
This is truly a miracle drug in the same way that penicillin, statin drugs, Covid vaccines, insulin and Sildenafil have demonstrated. We are lucky to live in this age of pharmaceutical advances and wonders.
I will report my progress which should allay some of your concerns about?Semaglutide and NAION.
Marc
|
SEX female
FIRST INCIDENT AGE 72
CURRENT AGE 74
SECOND INCIDENT AGE ?N/A
AFFECTED EYE YES, no acuity
UNAFFECTED EYE YES
USING OZEMPIC OR SIMILAR NO
HYPERTENSION NO
POSSIBLE NOCTURNAL HYPOTENSION NO
DIABETES NO
SLEEP APNOEA NO
CAUSAL RELATIONSHIP TO COVID ILLNESS NO
CAUSAL RELATIONSHIP TO COVID VACCINE NO
STILL DRIVING During the day
OTHER - small cup/disc both eyes
On Mon, Mar 17, 2025 at 1:45?AM Chiarina Blake via <jc.blake2= [email protected]> wrote: I’LL START
SEX female
FIRST INCIDENT AGE 58
CURRENT AGE 64
SECOND INCIDENT AGE ?N/A
AFFECTED EYE YES
UNAFFECTED EYE YES
USING OZEMPIC OR SIMILAR NO
HYPERTENSION No
POSSIBLE NOCTURNAL HYPOTENSION yes
DIABETES NO
SLEEP APNOEA Yes
CAUSAL RELATIONSHIP TO COVID ILLNESS No
CAUSAL RELATIONSHIP TO COVID VACCINE No
STILL DRIVING No
OTHER? NAION affected my only good functioning eye. I was born with an under developed retina in my other eye. Confirmed cause of my attack was Sleep Apnea On Mon, 17 Mar 2025 at 3:59?pm, Terry Berelowitz via <craigberelowitz= [email protected]> wrote: HULLO ALL
FEAR OF NAION AFFECTING OUR HEALTHY EYE LIVES WITH ALL OF US
WE LOOK AT THE STATS FOR REASSURANCE
IT WOULD BE SO HELPFUL, I’M SURE TO ALL TO HAVE A QUICK SURVEY IN OUR GROUP
PKEASE DO ANSWER SO THAT WE CAN APPRECIATE THE REAL PICTURE
I’LL START
SEX MALE
FIRST INCIDENT AGE 62
CURRENT AGE 66
SECOND INCIDENT AGE ?N/A
COMPROMISED DISC CUP RATIO?
AFFECTED EYE YES
UNAFFECTED EYE YES
USING OZEMPIC OR SIMILAR NO
HYPERTENSION YES
POSSIBLE NOCTURNAL HYPOTENSION
DIABETES NO
SLEEP APNOEA NO
CAUSAL RELATIONSHIP TO COVID ILLNESS MAYBE
CAUSAL RELATIONSHIP TO COVID VACCINE MAYBE
STILL DRIVING YES
OTHER?
THIS WILL BE AN INVALUABLE SURVEY
PLEASE DO ANSWER
THANK YOU
TERRY
MEDICAL SPECIALIST On Mon, 17 Mar 2025 at 05:29, George Ousler via <sailfishin= [email protected]> wrote:
Hi Marc,
Thanks for your post. I feel obligated to let you know that I was in your shoes not too long ago (March 2024) and unfortunately suffered from a second NAION in my neighboring eye after using a GLP (Mounjorno) for approximately 6 months. I completely understand the risk vs. benefit ratio and that the improvements from weight loss, etc. are tremendous but I have to say that the potential loss of vision in both eyes is devastating. Once you have a NAION in both eyes, there may be significant blind spots based on the areas between your two eyes that overlap and therefore have true total vision loss (when there is only one eye involved, the neighboring eye compensates to the point where you don't notice the vision loss). I'm not suggesting that you change your opinion / plan, rather, just be sure that you can't control your diabetes, etc. through diet, other medications, etc. to try to prevent an ischemic event from GLP induced decreased blood flow. Also, do you have crowded disc syndrome (small cup to disc ratio in both eyes)? As you know, once it occurs, you can't reverse it. I've been seeing a neuro-ophthalmologist at Mass Eye and Eye who has been researching and publishing on the association between NAION and GLPs. Please google Dr. Rizzo at Mass General Hospitals and NAION to learn more. Happy to discuss more Marc (and anyone else in this group) to share my experience - once you have a second NAION, the game changes significantly. Thanks.
George ?
On Sunday, March 16, 2025 at 10:57:23 PM EDT, Marc Gold via <marcgold= [email protected]> wrote:
The evidence of a link between Semaglutide and NAION is indeed very weak. I already have NAION in one eye.? The improvement of my diabetes, weight, heart and kidney status worries me far more than the small chance my other eye could be affected by Ozempic. I start Ozempic next week @ 1 mg. per week. My physician concurs that the benefits far outweigh the risks. I'll take my chances, which are not high at all: Even though we have demonstrated a higher risk of NAION in persons with T2D exposed to once-weekly semaglutide, it is important to keep in mind that use of semaglutide comes with substantial advantages for patients as given by the improved glycemic control, reduction in risk of cardiovascular disease as well as the beneficial effects of weight loss [1]. As such, the observed incidence rate of NAION of 0·228 per 1000 person-years for persons with T2D exposed with once-weekly semaglutide may not discourage semaglutide treatment but needs to be acknowledged as a potential risk. This is truly a miracle drug in the same way that penicillin, statin drugs, Covid vaccines, insulin and Sildenafil have demonstrated. We are lucky to live in this age of pharmaceutical advances and wonders.
I will report my progress which should allay some of your concerns about?Semaglutide and NAION.
Marc
-- Diane Keasler DLKeasler@...
Life is the school, love is the lesson.
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I’LL START
SEX female
FIRST INCIDENT AGE 58
CURRENT AGE 64
SECOND INCIDENT AGE ?N/A
AFFECTED EYE YES
UNAFFECTED EYE YES
USING OZEMPIC OR SIMILAR NO
HYPERTENSION No
POSSIBLE NOCTURNAL HYPOTENSION yes
DIABETES NO
SLEEP APNOEA Yes
CAUSAL RELATIONSHIP TO COVID ILLNESS No
CAUSAL RELATIONSHIP TO COVID VACCINE No
STILL DRIVING No
OTHER? NAION affected my only good functioning eye. I was born with an under developed retina in my other eye. Confirmed cause of my attack was Sleep Apnea On Mon, 17 Mar 2025 at 3:59?pm, Terry Berelowitz via <craigberelowitz= [email protected]> wrote:
HULLO ALL
FEAR OF NAION AFFECTING OUR HEALTHY EYE LIVES WITH ALL OF US
WE LOOK AT THE STATS FOR REASSURANCE
IT WOULD BE SO HELPFUL, I’M SURE TO ALL TO HAVE A QUICK SURVEY IN OUR GROUP
PKEASE DO ANSWER SO THAT WE CAN APPRECIATE THE REAL PICTURE
I’LL START
SEX MALE
FIRST INCIDENT AGE 62
CURRENT AGE 66
SECOND INCIDENT AGE ?N/A
COMPROMISED DISC CUP RATIO?
AFFECTED EYE YES
UNAFFECTED EYE YES
USING OZEMPIC OR SIMILAR NO
HYPERTENSION YES
POSSIBLE NOCTURNAL HYPOTENSION
DIABETES NO
SLEEP APNOEA NO
CAUSAL RELATIONSHIP TO COVID ILLNESS MAYBE
CAUSAL RELATIONSHIP TO COVID VACCINE MAYBE
STILL DRIVING YES
OTHER?
THIS WILL BE AN INVALUABLE SURVEY
PLEASE DO ANSWER
THANK YOU
TERRY
MEDICAL SPECIALIST On Mon, 17 Mar 2025 at 05:29, George Ousler via <sailfishin= [email protected]> wrote:
Hi Marc,
Thanks for your post. I feel obligated to let you know that I was in your shoes not too long ago (March 2024) and unfortunately suffered from a second NAION in my neighboring eye after using a GLP (Mounjorno) for approximately 6 months. I completely understand the risk vs. benefit ratio and that the improvements from weight loss, etc. are tremendous but I have to say that the potential loss of vision in both eyes is devastating. Once you have a NAION in both eyes, there may be significant blind spots based on the areas between your two eyes that overlap and therefore have true total vision loss (when there is only one eye involved, the neighboring eye compensates to the point where you don't notice the vision loss). I'm not suggesting that you change your opinion / plan, rather, just be sure that you can't control your diabetes, etc. through diet, other medications, etc. to try to prevent an ischemic event from GLP induced decreased blood flow. Also, do you have crowded disc syndrome (small cup to disc ratio in both eyes)? As you know, once it occurs, you can't reverse it. I've been seeing a neuro-ophthalmologist at Mass Eye and Eye who has been researching and publishing on the association between NAION and GLPs. Please google Dr. Rizzo at Mass General Hospitals and NAION to learn more. Happy to discuss more Marc (and anyone else in this group) to share my experience - once you have a second NAION, the game changes significantly. Thanks.
George ?
On Sunday, March 16, 2025 at 10:57:23 PM EDT, Marc Gold via <marcgold= [email protected]> wrote:
The evidence of a link between Semaglutide and NAION is indeed very weak. I already have NAION in one eye.? The improvement of my diabetes, weight, heart and kidney status worries me far more than the small chance my other eye could be affected by Ozempic. I start Ozempic next week @ 1 mg. per week. My physician concurs that the benefits far outweigh the risks. I'll take my chances, which are not high at all: Even though we have demonstrated a higher risk of NAION in persons with T2D exposed to once-weekly semaglutide, it is important to keep in mind that use of semaglutide comes with substantial advantages for patients as given by the improved glycemic control, reduction in risk of cardiovascular disease as well as the beneficial effects of weight loss [1]. As such, the observed incidence rate of NAION of 0·228 per 1000 person-years for persons with T2D exposed with once-weekly semaglutide may not discourage semaglutide treatment but needs to be acknowledged as a potential risk. This is truly a miracle drug in the same way that penicillin, statin drugs, Covid vaccines, insulin and Sildenafil have demonstrated. We are lucky to live in this age of pharmaceutical advances and wonders.
I will report my progress which should allay some of your concerns about?Semaglutide and NAION.
Marc
|
HULLO ALL
FEAR OF NAION AFFECTING OUR HEALTHY EYE LIVES WITH ALL OF US
WE LOOK AT THE STATS FOR REASSURANCE
IT WOULD BE SO HELPFUL, I’M SURE TO ALL TO HAVE A QUICK SURVEY IN OUR GROUP
PKEASE DO ANSWER SO THAT WE CAN APPRECIATE THE REAL PICTURE
I’LL START
SEX MALE
FIRST INCIDENT AGE 62
CURRENT AGE 66
SECOND INCIDENT AGE ?N/A
COMPROMISED DISC CUP RATIO?
AFFECTED EYE YES
UNAFFECTED EYE YES
USING OZEMPIC OR SIMILAR NO
HYPERTENSION YES
POSSIBLE NOCTURNAL HYPOTENSION
DIABETES NO
SLEEP APNOEA NO
CAUSAL RELATIONSHIP TO COVID ILLNESS MAYBE
CAUSAL RELATIONSHIP TO COVID VACCINE MAYBE
STILL DRIVING YES
OTHER?
THIS WILL BE AN INVALUABLE SURVEY
PLEASE DO ANSWER
THANK YOU
TERRY
MEDICAL SPECIALIST
On Mon, 17 Mar 2025 at 05:29, George Ousler via <sailfishin= [email protected]> wrote:
Hi Marc,
Thanks for your post. I feel obligated to let you know that I was in your shoes not too long ago (March 2024) and unfortunately suffered from a second NAION in my neighboring eye after using a GLP (Mounjorno) for approximately 6 months. I completely understand the risk vs. benefit ratio and that the improvements from weight loss, etc. are tremendous but I have to say that the potential loss of vision in both eyes is devastating. Once you have a NAION in both eyes, there may be significant blind spots based on the areas between your two eyes that overlap and therefore have true total vision loss (when there is only one eye involved, the neighboring eye compensates to the point where you don't notice the vision loss). I'm not suggesting that you change your opinion / plan, rather, just be sure that you can't control your diabetes, etc. through diet, other medications, etc. to try to prevent an ischemic event from GLP induced decreased blood flow. Also, do you have crowded disc syndrome (small cup to disc ratio in both eyes)? As you know, once it occurs, you can't reverse it. I've been seeing a neuro-ophthalmologist at Mass Eye and Eye who has been researching and publishing on the association between NAION and GLPs. Please google Dr. Rizzo at Mass General Hospitals and NAION to learn more. Happy to discuss more Marc (and anyone else in this group) to share my experience - once you have a second NAION, the game changes significantly. Thanks.
George ?
On Sunday, March 16, 2025 at 10:57:23 PM EDT, Marc Gold via <marcgold= [email protected]> wrote:
The evidence of a link between Semaglutide and NAION is indeed very weak. I already have NAION in one eye.? The improvement of my diabetes, weight, heart and kidney status worries me far more than the small chance my other eye could be affected by Ozempic. I start Ozempic next week @ 1 mg. per week. My physician concurs that the benefits far outweigh the risks. I'll take my chances, which are not high at all: Even though we have demonstrated a higher risk of NAION in persons with T2D exposed to once-weekly semaglutide, it is important to keep in mind that use of semaglutide comes with substantial advantages for patients as given by the improved glycemic control, reduction in risk of cardiovascular disease as well as the beneficial effects of weight loss [1]. As such, the observed incidence rate of NAION of 0·228 per 1000 person-years for persons with T2D exposed with once-weekly semaglutide may not discourage semaglutide treatment but needs to be acknowledged as a potential risk. This is truly a miracle drug in the same way that penicillin, statin drugs, Covid vaccines, insulin and Sildenafil have demonstrated. We are lucky to live in this age of pharmaceutical advances and wonders.
I will report my progress which should allay some of your concerns about?Semaglutide and NAION.
Marc
|
Re: Semaglutide and NAION
Hi Marc,
Thanks for your post. I feel obligated to let you know that I was in your shoes not too long ago (March 2024) and unfortunately suffered from a second NAION in my neighboring eye after using a GLP (Mounjorno) for approximately 6 months. I completely understand the risk vs. benefit ratio and that the improvements from weight loss, etc. are tremendous but I have to say that the potential loss of vision in both eyes is devastating. Once you have a NAION in both eyes, there may be significant blind spots based on the areas between your two eyes that overlap and therefore have true total vision loss (when there is only one eye involved, the neighboring eye compensates to the point where you don't notice the vision loss). I'm not suggesting that you change your opinion / plan, rather, just be sure that you can't control your diabetes, etc. through diet, other medications, etc. to try to prevent an ischemic event from GLP induced decreased blood flow. Also, do you have crowded disc syndrome (small cup to disc ratio in both eyes)? As you know, once it occurs, you can't reverse it. I've been seeing a neuro-ophthalmologist at Mass Eye and Eye who has been researching and publishing on the association between NAION and GLPs. Please google Dr. Rizzo at Mass General Hospitals and NAION to learn more. Happy to discuss more Marc (and anyone else in this group) to share my experience - once you have a second NAION, the game changes significantly. Thanks.
George ?
On Sunday, March 16, 2025 at 10:57:23 PM EDT, Marc Gold via groups.io <marcgold@...> wrote:
The evidence of a link between Semaglutide and NAION is indeed very weak. I already have NAION in one eye.? The improvement of my diabetes, weight, heart and kidney status worries me far more than the small chance my other eye could be affected by Ozempic. I start Ozempic next week @ 1 mg. per week. My physician concurs that the benefits far outweigh the risks. I'll take my chances, which are not high at all: Even though we have demonstrated a higher risk of NAION in persons with T2D exposed to once-weekly semaglutide, it is important to keep in mind that use of semaglutide comes with substantial advantages for patients as given by the improved glycemic control, reduction in risk of cardiovascular disease as well as the beneficial effects of weight loss [1]. As such, the observed incidence rate of NAION of 0·228 per 1000 person-years for persons with T2D exposed with once-weekly semaglutide may not discourage semaglutide treatment but needs to be acknowledged as a potential risk. This is truly a miracle drug in the same way that penicillin, statin drugs, Covid vaccines, insulin and Sildenafil have demonstrated. We are lucky to live in this age of pharmaceutical advances and wonders.
I will report my progress which should allay some of your concerns about?Semaglutide and NAION.
Marc
|
The evidence of a link between Semaglutide and NAION is indeed very weak. I already have NAION in one eye.? The improvement of my diabetes, weight, heart and kidney status worries me far more than the small chance my other eye could be affected by Ozempic. I start Ozempic next week @ 1 mg. per week. My physician concurs that the benefits far outweigh the risks. I'll take my chances, which are not high at all: Even though we have demonstrated a higher risk of NAION in persons with T2D exposed to once-weekly semaglutide, it is important to keep in mind that use of semaglutide comes with substantial advantages for patients as given by the improved glycemic control, reduction in risk of cardiovascular disease as well as the beneficial effects of weight loss [1]. As such, the observed incidence rate of NAION of 0·228 per 1000 person-years for persons with T2D exposed with once-weekly semaglutide may not discourage semaglutide treatment but needs to be acknowledged as a potential risk. This is truly a miracle drug in the same way that penicillin, statin drugs, Covid vaccines, insulin and Sildenafil have demonstrated. We are lucky to live in this age of pharmaceutical advances and wonders.
I will report my progress which should allay some of your concerns about?Semaglutide and NAION.
Marc
|
Re: Semaglutide and NAION
Well, yes! I thought everyone with NAION does to some extent. I was stricken about eight weeks ago. Right eye only, but I’m guessing I’ve lost 90+% of vision. Don’t recognize my wife 3 ft away from me. I have very controlled Type 2 diabetes for which I took relatively low dose of Ozempic (never more than 1 mg) from last August through January of this year. I believe that’s what triggered NAION, but I guess I’ll never know for sure. I have had sleep apnea for 15 years, well controlled and faithful user of CPAP.
Like others commenting here, greatest worry is if it affects other eye, chances of which are raised due to a relatively low disk/cup ratio of 0.25.
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On Mar 15, 2025, at 02:17, Chiarina Blake via groups.io <jc.blake2@...> wrote:
? Hi there and good on you for posting. Yes. I have blurred vision in my only good working eye. Glasses only help to a certain extent. Only slightly. That’s because it’s a brain to eye issue and not a typical refractive issue. It sucks? Have you been tested for sleep Apnea? I got mine because I had severe Sleep Apnea and did nothing about it. Now I use a CPAP machine. If you are overweight like me, sleep apnea is a common cause of NAION.? Take care? On Sat, 15 Mar 2025 at 4:39?am, Dianne Best via <Diannebest31= [email protected]> wrote: Hi
Been following this group a couple of years now; but never posted before. I got NAION in both eyes 2 to 3 years ago. Approx 6 months prior I took Saxenda weight loss injections for about 5 months; stopping about 2 months prior to NAION attack. I only took low doses because they made me feel ill. I do not have diabetes, but was overweight. I am now almost blind in one eye and the other eye is badly affected. My peripheral vision is poor and my vision is permanently blurred. I believe the weight loss drug probably caused the NAION. I have seen a number of articles stating the increase in NAION in people taking these drugs. I thought it important to share this info .
NB does anyone else with NAION have permanently blurred vision?
Thanks
Dianne
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Re: Semaglutide and NAION
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Show quoted text
On 15 Mar 2025, at 06:17, Chiarina Blake via groups.io <jc.blake2@...> wrote:
?
Hi there and good on you for posting. Yes. I have blurred vision in my only good working eye. Glasses only help to a certain extent. Only slightly. That’s because it’s a brain to eye issue and not a typical refractive issue. It sucks?
Have you been tested for sleep Apnea? I got mine because I had severe Sleep Apnea and did nothing about it. Now I use a CPAP machine. If you are overweight like me, sleep apnea is a common cause of NAION.?
Take care?
On Sat, 15 Mar 2025 at 4:39?am, Dianne Best via
<Diannebest31= [email protected]> wrote:
Hi
Been following this group a couple of years now; but never posted before. I got NAION in both eyes 2 to 3 years ago. Approx 6 months prior I took Saxenda weight loss injections for about 5 months; stopping about 2 months prior to NAION attack. I only took low
doses because they made me feel ill. I do not have diabetes, but was overweight. I am now almost blind in one eye and the other eye is badly affected. My peripheral vision is poor and my vision is permanently blurred. I believe the weight loss drug probably
caused the NAION. I have seen a number of articles stating the increase in NAION in people taking these drugs. I thought it important to share this info .
NB does anyone else with NAION have permanently blurred vision?
Thanks
Dianne
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