clip on ferrites are you friend here
one at each end of the USB cable,
also do you have a common mode choke on the feeder?
Peter
M0PWX
It might be an interference from the your antenna to USB
cable - PC lose connection with transceiver during TX. Try to
repeat with 0.1W output power. If it will help - replace USB
cable with shielded, or/and add some chokes to the USB/antenna
cable.
--
Peter
M0PWX