As others have said MTR2000's CPS only runs on a Windows 32bit OS. I have a Windows 10 Pro 32bit installation that works fine using a USB to Serial adapter, I have an old Windows XP Pro computer with a conventional serial port that works fine and a Window 10 Pro 64 bit laptop that I run a VirtualBox VM running Windows XP Pro with a USB to Serial adapter which also works fine (for other 32 bit CPS's too).
For a cable I use a CAT5 patch cable to a RJ-45 to DB-9F adapter with just the 3 needed wires connected.? When I worked for an MSS to simplify the cables I had to carry, I had a bunch of these same adapters configured and labeled for different radios and equipment that required serial connections with or without a RIB.? Wicked easy to setup and you don't even need a soldering iron! (Although an extraction tool is handy if you screw up)
Assuming your Windows installations are OK, 99% of the time it is a driver or driver installation issue.? Check the device manager to start with.? Also as others have also mentioned Prolific drivers especially new ones can be problematic and drive you nuts. see:
P.S. - I too have purchased a couple cables from BlueMAx49 with no issues.
Good Luck
73
Jon
K1IMD