How would you do it?
I'm thinking that first, I'd need to construct an adapter for the VNA - sma connector, short length of coax, with clips on the center conductor and shield to clip to the two sides of the ladder line (but, the quality of the connection between the clips and the ladder line wires (among other things) is going to introduce variables, right?)
Second, I should calibrate for the desired frequency range using the adapter as described above, in order to "calibrate out" as much of the peculiarities of the measurement system as I can - I would clip my adapter to my QRP-Labs dummy load for the load part, leave the clips dangling for the open, and clip them together for the through.
What kind of trouble am I going to be getting myself into?