Hello Rob,
By GUI I guess you mean the Config/radio/Hardware screen. You can change this to anything you want by creating another "Radio" in the file quisk_conf_defaults.py. There are many radios there to serve as examples. But then you must connect the GUI values to the Quisk engine to use them.
The phase and amplitude balance buttons are grayed out because you are not using a soundcard. Even if they were active, you still need to insert the corrections into the data stream.
Jim
N2ADR