Hi Yves and everybody,
I managed it! Indeed I changed two lines in the "hardware_usb.py" file. The QRP2000 signal generator essentially in Quisk connects to the PC via the USB port like Softrock, but in the "hardware_usb.py" file there are two lines containing " * 4 ", and that is where the frequency is multiplied by 4. Removing the * 4 the QRP2000 to generate the frequency 3.5Mhz actually generates 3.5Mhz and not 14Mhz (= 3.5Mhz * 4) anymore.
Then regarding the 10.7Mhz offset, it's trivial as I use the transverter option in the menu of Quisk in "bands" (just like Softrock) and to receive a 3.5Mhz with a 10.7Mhz intermediate frequency I set the offset to "- 10700000".
It's very simple! The terminal command rigctl -vvvvv -m 2509 get_freq was very useful to check the generated frequency.
That's all, thank you! And I hope other QRP2000 owners will be using Quisk!
Franco iz2oos