I have used many Global Cache Flex adapters with serial cable from VC4 to multiple models of Cisco Room Devices with no issues. Funny thing is, the first time when I chose to use one, it was due to problematic communication from a Series 3 DMPS com port that would stop working after a time for unknown reasons. Connecting the GC via TCP/IP to the DMPS and then serial to the Cisco solved the problem.?