After getting a new programming laptop, I noticed that the default user database locations for IR and modules was relocated to the "Public Documents" folder.
I'm assuming that this is due to all of the new "security" implementations in Windows 11 (FIPS/UAC).
I'd bet that if you relocated your UserDB, Usrmacro, and Usrsplus libraries to the public or your local user documents folder, then everything would work fine after changing the directory locations in Simpl, etc.
Good luck,
Brian