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Cannot say I've notice any issue trying to open multiple instances of SIMPL -- even with the version of SIMPL that came out last month.? But instead of double clicking the SIMPL file to open it, I always open it by right clicking it and selecting Open.? And when task switching between SIMPL programs, I just hoover my mouse of the SIMPL icon on the task bar and select the program I want to switch to from there.

But the thing I have notice with the Series 4 and and the latest versions of Crestron software is it seems that things have gotten so Slow.? Compile times seem to be much longer and things just crash sometimes.? And I thought the series 4 processors where suppose to be so much quicker.? All I know is when I program a Series 2 or 3 nowadays, it seems to go so much quicker and smoother.? But I might add that when I program in Series 2 or 3 today, I use Crestron software from the early 2020 before the software could do a Series 4.? It is only when I program a Series 4 do I use the latest software.

One final note however is I do all my SIMPL/SIMPL+/VTPRO programming from a Windows 7 VM. So Windows 10 or 11 may be different. I only use a Windows 10 VM for SIMPL# as I highly doubt Visual Studio 2019 would work on Windows 7. Just don't like dealing with the bloat and constant updates with Window 10.? Of course I don't surt the Internet with Windows 7 (nor Windows 10 as that goes) and all my Windows VMs are destroyed after each use so any corruption that may occur gets wiped clean after a session.

YMMV