We have systems running like this and they have been working well. The IT guys did the VLAN setup, so I don't know configuration specifics. In one case I have 10 TVs with RS232 control over the local NVX units and it has never failed.
Side note, when I was initially setting this up and having some issues, I called Tech support and they said 'Nope, you can't do that', while at the same time our IT guys got it all working. TB then said 'Oh, yes, you can do that.'