Hi there! It is actually pretty straightforward to use the QY Data filer on a modern mac (tested on M1 mbp), but counterintuitively, the easiest method is via the Windows version of the application.
You don't need a deal with the complexity of a virtual machine, as it runs perfectly via / WINE. This means it has direct access to any connected MIDI interface without special setup.
I've found that a good number of older windows apps I've tried for MIDI-related tasks run quite stably this way, such as SoundDiver and XGWorks.
Hope that helps!
dusk