Dud
I too have some difficulty differentiating generics from original .
I rely??on big company names ,price and country of manufacture.
India and China famous for cheap generics .
?The weight fraction can be estimated in the low mg/kg-range??like in PDE limits but a poisonous ingredient in a pill is surprising and should be avoided .On top of that is coming from the filler to make it marketable.
Paracelsus law of dose related toxicity should??not be applied to tablets in my opinion.
They can find an alternative filler material or something.
Anyway I did a quick scan on some generic aspirin.There was no high Ca peak .Only Fe stood?
Anyway a longer scan need to be done with proper sample preparation?
Taray
On Friday, January 29, 2021, 4:07 AM, Dude <dfemer@...> wrote:
Very interesting on the
aspirin Both have about the same Rh but the Ca is way different, amongst other
things.? I may have to try this although the levels may be below my delectability.
I have some Colpidogrel I¡¯ll try as well.
How do I determine generic
from big boy stuff?
Dud
?https://www.agilent.com/cs/library/applications/5991-8337EN_usp_233_icpoes_application.pdf
?
?
Hi guys
Pharmaceuticals have some active ingredients but their main components?
are fillers.
These? fillers have some functions which? are not? necessarily
therapeutic but can influence the tolerance to a drug.
But they can be? ?used for identification of manipulated
products? such as presence? of inorganic compounds? especially
in some generics.
As a reference I have provided a micro xrf lab results of a sample of Aspirin
Baeyer original and a generic.
The generic filler has more inorganic compounds? compared to the original
Pb is astonishingly present in the generic
Unfortunately Pb residual peaks makes it difficult to make an? analysis
regarding the presence of lead with Am setup
Here I am using generic form of clopidogrel a common antiplatelet
medication? better? known as Plavix
My sample is a few tablets in a polyethylene? container.
Ideally should be ground to a flat sheet for xrf
Anyway my xrf show peaks of Ti? and? Fe like the lab results
Best stay away from generics for long term usage drugs
Taray
