If you're using UI-View to send your Wx info, then you can alter your callsign in the 'Wx Station Setup" window under the 'Setup' menu
Your weather station will need to somehow write a wxnow.txt file containing the latest Wx info in the right format (see below) & then you tell UIView to use that file, or perhaps you have a another program that receives the data from the Wx Station maybe via a serial port, and does that job for you. "Weather Display" is one that springs to mind.
One issue you might have with Windows 10 is that it doesn't like programs writing things to the 'Program Files' folder or anything under it, so any changes that you make that get stored in the UIVIEW.INI file, won't stick.
The solution is to install UIview somewhere outside of the 'Program Files' - say 'C:\HamProgs\UIView' and then Windows 10 won't stop the changes you make.
You might also like to read this webpage for more info on this (about 1/2 way down)
Weather Data Format
Here, between the two lines of '*'s is the format of the file your wx software needs to create (the lines of '*'s are not part of the file).
****
Jun 01 2003 08:07
272/000g006t069r010p030P020h61b10150
****
where the various parts of the data string are -:
272 - wind direction - 272 degrees
010 - wind speed - 10 mph
g015 - wind gust - 15 mph
t069 - temperature - 69 degrees F
r010 - rain in last hour in hundredths of an inch - 0.1 inches
p030 - rain in last 24 hours in hundredths of an inch - 0.3 inches
P020 - rain since midnight in hundredths of an inch - 0.2 inches
h61 - humidity 61% (00 = 100%)
b10153 - barometric pressure in tenths of a millibar - 1015.3 millibars
-Ian ZL1VFO