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Re: Bronze Age spread of R-U106 from ancient DNA

 

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Wikipedia is not the place for publishing original research. It is an encyclopedia which collates material from reliable published sources. One of the core policies of Wikipedia is that there should be no original research:

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Best wishes

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Debbie Kennett

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From: [email protected] <[email protected]> On Behalf Of Roy via groups.io
Sent: 28 December 2024 20:02
To: [email protected]
Subject: Re: [R1b-U106] Bronze Age spread of R-U106 from ancient DNA

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Your modesty aside, I don't think that a paragraph for a Wikipedia article would be subject to the same rigorous review as an academic journal. Or at any rate the custodians would be more open to discussion. To illustrate the point, in order to confirm my descent from an illegitimate son of the architect Sir William Bruce, I had to do a deep dive into the records. When I was satisfied that the link was confirmed by better than a preponderance of evidence, I added the information to the Wikipedia article on Bruce. Nobody raised any objections.

Moreover, I would suggest that a judicious leveraging of AI could push your project forward at a rate you might not have anticipated otherwise. I am using it for my physics projects and am rewriting the Yback machine in Python thanks to AI to incorporate libraries used in academic research.

Cheers, Roy

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On Sat, 28 Dec 2024 at 13:42, Iain via <gubbins=[email protected]> wrote:

Hi Roy,

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If I thought I could write something on the topic that would get past peer review, I would try! This is many steps below that, and it's not just references that are needed. A much more mathematical model to deal with these issues is sorely needed, but to create one properly would take me, I think, a second PhD. For now, this is just my garden-shed tinkering, given to the group in the hope of provoking discussion and raising interest.

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Cheers,

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Iain.


Re: Upcoming BAM Submissions Request Drive for YDNA Warehouse

 

James,
Happy New Year and a big thanks for all your hard work.

Bernie Leopold


On Sat, Jan 4, 2025, 8:47?AM James Kane via <jkane=[email protected]> wrote:

Hi folks,

Happy New Year!

I'm writing to get a head start on collecting BAM (Binary Alignment Map) files for an upcoming migration of the YDNA Warehouse tree to the hs1 reference genome in 2025. This update aligns with the data from the experimental group of R1b-FGC11134 samples currently in progress.

For most of you who have already provided a BAM, no further action is required. I'll process your data once I'm finished addressing DE and IJ subclades.

If you haven't provided a BAM or have upgraded to Big Y 700 since then, here's why submitting a current BAM is beneficial:

  • Smoother data realignment: Distributing submissions throughout this time will help with the realignment process to hs1. Registered members will receive a notification from info@... when it's crunch time to submit.
  • Updated Big Y STR Panels: This is an opportunity to update your Big Y STR panels, which you can compare with others in the (enrollment or investigator access required).
  • More precise tree inference: Upgraders, your additional ~5 million bases will significantly improve the accuracy of the tree.

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Privacy Considerations:

  • Your data security is our top priority. We employ robust technological safeguards and offer optional 2-factor authentication for your account.
  • All data shared publicly is completely de-identified. We use new kit numbers (Taxon IDs) and allow you to control the information displayed in reports (e.g., EKA details, kit aliases).

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Alternative File Formats:

If your lab charges extra for BAM files, VCF or BED formats are acceptable. However, integrating these files into the final tree position will require manual processing, which is currently backlogged for branches outside of mine. I'm finalizing tools to streamline this process in the future.

You’re Not R-U106:

Feel free to also start updating your files and sharing with your more specific subclade.? I’m starting with U106 when coming back to R1b, since it’s currently the furthest behind in updates.

Thanks for your time and participation!

James Kane


Connection Issues? Re: Upcoming BAM Submissions Request Drive for YDNA Warehouse

 

Hi again!
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Thanks for all the interest as a flash mob. You'll be seeing some sluggishness as the overgrown cell phone that hosts the site tries to keep up with you all accessing the new Study.

I'm adding a cache in front of the pain point and responsiveness will improve loading the Member List.
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James Kane


Upcoming BAM Submissions Request Drive for YDNA Warehouse

 

Hi folks,

Happy New Year!

I'm writing to get a head start on collecting BAM (Binary Alignment Map) files for an upcoming migration of the YDNA Warehouse tree to the hs1 reference genome in 2025. This update aligns with the data from the experimental group of R1b-FGC11134 samples currently in progress.

For most of you who have already provided a BAM, no further action is required. I'll process your data once I'm finished addressing DE and IJ subclades.

If you haven't provided a BAM or have upgraded to Big Y 700 since then, here's why submitting a current BAM is beneficial:

  • Smoother data realignment: Distributing submissions throughout this time will help with the realignment process to hs1. Registered members will receive a notification from info@... when it's crunch time to submit.
  • Updated Big Y STR Panels: This is an opportunity to update your Big Y STR panels, which you can compare with others in the (enrollment or investigator access required).
  • More precise tree inference: Upgraders, your additional ~5 million bases will significantly improve the accuracy of the tree.

?

Privacy Considerations:

  • Your data security is our top priority. We employ robust technological safeguards and offer optional 2-factor authentication for your account.
  • All data shared publicly is completely de-identified. We use new kit numbers (Taxon IDs) and allow you to control the information displayed in reports (e.g., EKA details, kit aliases).

?

Alternative File Formats:

If your lab charges extra for BAM files, VCF or BED formats are acceptable. However, integrating these files into the final tree position will require manual processing, which is currently backlogged for branches outside of mine. I'm finalizing tools to streamline this process in the future.

You’re Not R-U106:

Feel free to also start updating your files and sharing with your more specific subclade.? I’m starting with U106 when coming back to R1b, since it’s currently the furthest behind in updates.

Thanks for your time and participation!

James Kane


Re: Request for ancient DNA analysis

 

For what it's worth, I left a comment on the preprint asking if raw data was available.
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mike


Re: Request for ancient DNA analysis

 

preprint??and as far as I am aware, the raw data has not yet been made available.

Ray

On Fri, Jan 3, 2025 at 6:39?AM Raymond Wing <wing.genealogist@...> wrote:
These old Z18 samples are from a pre-print

On Fri, Jan 3, 2025 at 5:37?AM Iain via <gubbins=[email protected]> wrote:

Hi folks,

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I know that some of you have experience dealing with extracting calls from ancient DNA, and possibly more time than me to perform this kind of analysis.

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There are a lot of early ancient DNA samples that are typed as R-Z18 in , namely:

CGG107465
CGG106705
CGG106708
CGG106706
CGG105923
NEO752
CGG106744
CGG100212
NEO946

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These samples may be descended from the R-Z18 MRCA, or they may represent earlier "pre-R-Z18" individuals that are positive for some of the R-Z18 SNPs and negative for others. They may also belong to sub-clades that have not been tested for recently. However, the earlier samples among these (CGG107465 in particular) could have a bearing on the TMRCA of R-Z18 and its sub-clades, if we can establish that many of the R-Z18 SNPs are positive in these burials.

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What I'd really like is for someone to go through these burials and determine which SNPs are positive, from R-U106 down to the early branches of the R-Z18 tree. If someone's up for that, we may be able to make more concrete statements about R-Z18 and its expansion.

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Cheers,

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Iain.


Re: Request for ancient DNA analysis

 

These old Z18 samples are from a pre-print


On Fri, Jan 3, 2025 at 5:37?AM Iain via <gubbins=[email protected]> wrote:

Hi folks,

?

I know that some of you have experience dealing with extracting calls from ancient DNA, and possibly more time than me to perform this kind of analysis.

?

There are a lot of early ancient DNA samples that are typed as R-Z18 in , namely:

CGG107465
CGG106705
CGG106708
CGG106706
CGG105923
NEO752
CGG106744
CGG100212
NEO946

?

These samples may be descended from the R-Z18 MRCA, or they may represent earlier "pre-R-Z18" individuals that are positive for some of the R-Z18 SNPs and negative for others. They may also belong to sub-clades that have not been tested for recently. However, the earlier samples among these (CGG107465 in particular) could have a bearing on the TMRCA of R-Z18 and its sub-clades, if we can establish that many of the R-Z18 SNPs are positive in these burials.

?

What I'd really like is for someone to go through these burials and determine which SNPs are positive, from R-U106 down to the early branches of the R-Z18 tree. If someone's up for that, we may be able to make more concrete statements about R-Z18 and its expansion.

?

Cheers,

?

Iain.


Request for ancient DNA analysis

 

Hi folks,

?

I know that some of you have experience dealing with extracting calls from ancient DNA, and possibly more time than me to perform this kind of analysis.

?

There are a lot of early ancient DNA samples that are typed as R-Z18 in , namely:

CGG107465
CGG106705
CGG106708
CGG106706
CGG105923
NEO752
CGG106744
CGG100212
NEO946

?

These samples may be descended from the R-Z18 MRCA, or they may represent earlier "pre-R-Z18" individuals that are positive for some of the R-Z18 SNPs and negative for others. They may also belong to sub-clades that have not been tested for recently. However, the earlier samples among these (CGG107465 in particular) could have a bearing on the TMRCA of R-Z18 and its sub-clades, if we can establish that many of the R-Z18 SNPs are positive in these burials.

?

What I'd really like is for someone to go through these burials and determine which SNPs are positive, from R-U106 down to the early branches of the R-Z18 tree. If someone's up for that, we may be able to make more concrete statements about R-Z18 and its expansion.

?

Cheers,

?

Iain.


Re: Nature article - High-resolution genomic history of early medieval Europe

 

Very impressive research methods and execution!? We're finally getting somewhere...? Teasing some this out without any historical reference may be problematic however for historic-based claims to present-day territories. I'll be curious to see how these methods can be applied to pre-Roman as well as post-Roman populations in Great Britain.? The BBC have a story describing some of this as well: ?https://www.bbc.com/news/articles/clyx9nv4mleo


Phylogeography: R-U106 basal clades

 

Hi folks,

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As part of my , I've had a look through the R-U106 basal clades* and put together an assessment of their early migrations. (*I haven't looked at R-Z18 or R-Z381 yet but much of this will be true for them too.)

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The bottom line is that I've struggled to say anything very much about individual haplogroups with confidence, but there is a general sense that all of the basal clades of R-U106 probably formed during the initial migration of the haplogroup westwards into what's now northern Germany, but didn't stray far from there during the period between about 2900 and 2300 BC. There is later evidence of basal haplogroups in Denmark and Sweden, the Netherlands, Poland and even as far south as Spain, apparently travelling with the Bell Beaker Culture. (This analysis doesn't go as far forward as the Unetice culture.)

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The rest of R-U106 (and any replies) might take some time - as well as a rather tricksy time at home, I'm still nursing a hand injury. Please also bear in mind that this is probably everything I can say about each individual haplogroup, and not all of the results will be correct - this is still mainly guesswork!

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Happy New Year to all,

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Iain.


Re: Nature article - High-resolution genomic history of early medieval Europe

 

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This article has just featured on the main BBC News tonight, with a short clip of Pontus Skoglund talking about the impact of this work.? I will see if I can get the newsclip tomorrow, unless Debbie beats me to it.

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The BBC needed a good news story for New Year’s Day – and this was it.? To contrast with mayhem in New Orleans and floods in towns in the N.W. of England, etc.

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Brian

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From: [email protected] <[email protected]> On Behalf Of Clinton Platt via groups.io
Sent: 01 January 2025 17:11
To: [email protected]
Subject: [R1b-U106] Nature article - High-resolution genomic history of early medieval Europe

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Published 01 January 2025....

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High-resolution genomic history of early medieval Europe

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Abstract

Many known and unknown historical events have remained below detection thresholds of genetic studies because subtle ancestry changes are challenging to reconstruct. Methods based on shared haplotypes, and rare variants, improve power but are not explicitly temporal and have not been possible to adopt in unbiased ancestry models. Here we develop Twigstats, an approach of time-stratified ancestry analysis that can improve statistical power by an order of magnitude by focusing on coalescences in recent times, while remaining unbiased by population-specific drift. We apply this framework to 1,556 available ancient whole genomes from Europe in the historical period. We are able to model individual-level ancestry using preceding genomes to provide high resolution. During the first half of the first millennium CE, we observe at least two different streams of Scandinavian-related ancestry expanding across western, central and eastern Europe. By contrast, during the second half of the?first millennium CE, ancestry patterns suggest the regional disappearance or substantial admixture of these ancestries. In Scandinavia, we document a major ancestry influx by approximately 800 CE, when a large proportion of Viking Age individuals carried ancestry from groups related to central Europe not seen in individuals from the early Iron Age. Our findings suggest that time-stratified ancestry analysis can provide a higher-resolution lens for genetic history.


Nature article - High-resolution genomic history of early medieval Europe

 

Published 01 January 2025....
?
High-resolution genomic history of early medieval Europe
?
Abstract

Many known and unknown historical events have remained below detection thresholds of genetic studies because subtle ancestry changes are challenging to reconstruct. Methods based on shared haplotypes, and rare variants, improve power but are not explicitly temporal and have not been possible to adopt in unbiased ancestry models. Here we develop Twigstats, an approach of time-stratified ancestry analysis that can improve statistical power by an order of magnitude by focusing on coalescences in recent times, while remaining unbiased by population-specific drift. We apply this framework to 1,556 available ancient whole genomes from Europe in the historical period. We are able to model individual-level ancestry using preceding genomes to provide high resolution. During the first half of the first millennium CE, we observe at least two different streams of Scandinavian-related ancestry expanding across western, central and eastern Europe. By contrast, during the second half of the?first millennium CE, ancestry patterns suggest the regional disappearance or substantial admixture of these ancestries. In Scandinavia, we document a major ancestry influx by approximately 800 CE, when a large proportion of Viking Age individuals carried ancestry from groups related to central Europe not seen in individuals from the early Iron Age. Our findings suggest that time-stratified ancestry analysis can provide a higher-resolution lens for genetic history.


Re: English Wills (Was: Is your EKA information accurate?)

 

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Peter Wilson Coldham did find and index a huge number of Wills with references to Americans from the PCC Court.? I’m sure he thought he had collected everything that was easily accessible out there when he did that work.

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I have come across one case in my research where the clue to a Swann going to America in the 1650s was buried in the middle of a Chancery Case document.? So, there will be such items hidden out there.? Even now, work by some colleagues in America are unearthing treasures from digitized microfilms at FamilySearch – some of which go back to being filmed in the 1940s but never indexed before.

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It is always worth remembering with PCC Wills – that the Original Wills are held at the PCC as well, in Class PROB 10.? The Original Wills start later – around about 1487 from memory – the very first Will in Class PROB 10 has been endorsed to that effect by a former PRO Official, probably when the Public Record Office was first set up in the 1830s.

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I have found a few occasions where some words which the copy clerks thought were irrelevant to the probate of the Will were ignored when it came to making the copy – especially if it was an addendum at the bottom of a Will or a comment or endorsement on the exterior of the folded Will.? I’m pretty certain Coldham also examined all of these original Wills as well when he compiled his indexes – but I’ve never checked specifically what he says in the Introduction sections of his books – the part that most family historians never read, especially on Ancestry.

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The Original Wills can be easier to read quite often and can enable words or phrases which can be difficult to read in the Copy Wills on Ancestry far easier to decipher.? But they are bundled into boxes arranged by month and year of probate and then arranged inside the box into alphabetical bundles by surname, usually tied together by tags which can be difficult to open as few researchers go there - by the initial letter of the testator’s name.? You can work out the box required using the ‘Discovery’ and ‘Advanced Search’ features on the TNA website. You find the precise month and year of probate using the online index to all PROB 11 probates at the TNA, then search for that same month and year of probate using the PROB 10 description field in the ‘Class’ section of the search field. Sometimes a month of probates can be split across two boxes – with designations like A-D and E-Z to define which box you need to order up.

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Brian

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From: [email protected] <[email protected]> On Behalf Of Debbie via groups.io
Sent: 01 January 2025 16:33
To: [email protected]
Subject: Re: [R1b-U106] English Wills (Was: Is your EKA information accurate?)

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There is currently a major project at Exeter University which is using AI to transcribe 25,000 wills from the Prerogative Court of Canterbury. I am sure there will be many exciting discoveries. You can read about the project here:

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The project is highlighting interesting wills once a month on their blog:

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Debbie Kennett

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From: [email protected] <[email protected]> On Behalf Of Jim Cooke via groups.io
Sent: 01 January 2025 16:54
To: [email protected]
Cc: [email protected]
Subject: Re: [R1b-U106] Is your EKA information accurate?

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Genealogically speaking, when the English wills get transcribed (and some are being transcribed using AI) and made “available”, then turning AI loose with that info could do wonders for “Colonials” looking for British relatives.

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Jim


Re: English Wills (Was: Is your EKA information accurate?)

 

开云体育

There is currently a major project at Exeter University which is using AI to transcribe 25,000 wills from the Prerogative Court of Canterbury. I am sure there will be many exciting discoveries. You can read about the project here:

?

?

The project is highlighting interesting wills once a month on their blog:

?

?

Debbie Kennett

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From: [email protected] <[email protected]> On Behalf Of Jim Cooke via groups.io
Sent: 01 January 2025 16:54
To: [email protected]
Cc: [email protected]
Subject: Re: [R1b-U106] Is your EKA information accurate?

?

Genealogically speaking, when the English wills get transcribed (and some are being transcribed using AI) and made “available”, then turning AI loose with that info could do wonders for “Colonials” looking for British relatives.

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Jim


Re: Is your EKA information accurate?

 

Good Morning. I do very extensive genealogy research with many services. Some use AI. I have found AI can be a useful tool, but it has its’ limitations. Occasionally AI interprets information completely wrong. Additionally, it does not give you the true meaning of the document. There are many tools that will help decipher and interpret documents. I find it useful best not to use AI where other tools are available. I have extensive trees that date my German and English heritage back to the 1500s or more. AI will never replace humans. AI cannot think, it interprets. The one given being is that if you make one simple mistake it can cause your trees to be complete wrong. AI cannot spot those mistakes. Genealogy is a slow and deliberate science

Happy New Year

Mike Thompson

On Tue, Dec 31, 2024 at 4:32?PM Gary M. via <gddmorrison=[email protected]> wrote:
Even more impressive that a machine composed it.

It is impressive, but it raises the issue of what may be the uses and abuses of Ai in the realm of genealogy. Has anyone looked into this?

Regards, and best wishes to all for a healthy and happy New Year!

--
GaryM.


Re: Is your EKA information accurate?

 

开云体育

Genealogically speaking, when the English wills get transcribed (and some are being transcribed using AI) and made “available”, then turning AI loose with that info could do wonders for “Colonials” looking for British relatives.

Jim

On Jan 1, 2025, at 10:40?AM, Roy via groups.io <node999@...> wrote:

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Happy New Year to all.
My view has always been that the value of technology lies mainly in the users intent. However, with AI things become somewhat blurred.
Roy


Re: Is your EKA information accurate?

 

Happy New Year to all.
My view has always been that the value of technology lies mainly in the users intent. However, with AI things become somewhat blurred.

Roy


Re: Is your EKA information accurate?

 

开云体育

Yes..I have “toyed” with the AI modules in MyHeritage.

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From a computer science perspective, I found it both interesting and impressive in some regards.

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As a social scientist/genealogist, it was a stark reminder that AI can be a useful tool, but is no substitute for human expertise and knowledge.

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Richard

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From: [email protected] <[email protected]> On Behalf Of Gary M. via groups.io
Sent: Tuesday, December 31, 2024 1:32 PM
To: [email protected]
Subject: Re: [R1b-U106] Is your EKA information accurate?

?

Even more impressive that a machine composed it.

?

It is impressive, but it raises the issue of what may be the uses and abuses of Ai in the realm of genealogy. Has anyone looked into this?



Regards, and best wishes to all for a healthy and happy New Year!


--
GaryM.


Re: Is your EKA information accurate?

 

开云体育

Tried it when I researched the Cookes of West Sussex.

AI needs more access to be useful.


On Dec 31, 2024, at 4:32?PM, Gary M. via groups.io <gddmorrison@...> wrote:

?
Even more impressive that a machine composed it.

It is impressive, but it raises the issue of what may be the uses and abuses of Ai in the realm of genealogy. Has anyone looked into this?

Regards, and best wishes to all for a healthy and happy New Year!

--
GaryM.


Re: Is your EKA information accurate?

 

开云体育

Even more impressive that a machine composed it.

It is impressive, but it raises the issue of what may be the uses and abuses of Ai in the realm of genealogy. Has anyone looked into this?

Regards, and best wishes to all for a healthy and happy New Year!

--
GaryM.