I don't think it is reasonable to suggest that Big Y is inadequate.
?
For one thing, most of the 80 million bases are phylogenetically unhelpful. ?For this reason, full sequencing of the Y-chromosome - even if it were commercially available, which I don't think it currently is - provides only an incremental benefit over conventional sequencing with realignment to the novel reference.
I suspect affordable long-read sequencing is many years away. ?And when it IS available I think most of us will find the marginal benefit to be minimal.
Vince
On Sat, Jun 22, 2024 at 07:48 AM, <6458923@...> wrote:
The Big700 offers very inadequate coverage for the T2T reference, offering around 25 million bases. Human Ydna, on the other hand, can reach approximately 80 million bases, although this varies from person to person with recent studies.?
