Re: BigY - is it worth it?
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Hello Iain: ? Your response inspired me to do a browse of the research literature. ? I found some very interesting pieces that made me think again about the role of ?STRs. I now see a greater complementarity between the ?autosomal, Y-STR and Big-Y SNP elements. ? There may be indeed be something of interest in the ¡°murky world¡±. ? Here are the links. ?
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? Cheers ? Richard ?
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From: [email protected] <[email protected]> On Behalf Of Iain via groups.io
Sent: Friday, April 26, 2024 1:37 PM
To: [email protected]
Subject: Re: [R1b-U106] BigY - is it worth it?? Hi Richard, ? The recombinations that Thomas Hunt Morgan discusses on the autosomes don't apply to the male-specific Y chromosome, because it doesn't recombine. For the autosomal DNA, I'll leave that to more experienced people on here. ? For the Y chromosomal mutations, there is no specific evidence to suggest that they are not random. However, there is a murky world down there that operates on much longer timescales than individual mutations. There do seem to be some "preferred" values for some STRs, whether this is due to structural stability of folding on the chromosome or something similar, I don't think is known. At some point, STR lengths have to be non-zero, otherwise the STRs disappear. The STR mutation rates do also seem to have some variation between haplogroup, though this is mostly down to systematic differences in the average STR length in specific haplogroups, because longer STRs have more repeats to mutate. There is a lot of this stuff that we simply haven't had the opportunity or databases to look at in detail. ? Cheers, ? Iain.
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