Re: Match on block tree but not listed as Big Y Match
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Hi Iain,?
Thank you for your reply.
Yes, that¡¯s what I observe in my match. Ultimately, when the number of bigY tests will have increased considerably, the number of resilient PVs should drop considerably, and undoubtedly lose their interest.
Aren't some recurring SNPs also likely to one day be deleted from NMV lists? I suppose, given the imperfection of the GRCh38 reference, that some of these may be somehow "puppets", and not actually imply a valid mutation between 2 tests. If we were to one day move to a new comprehensive reference, taking into account the entire Y chromosome (and the rest of the human genome), as well as all its variations (also including all the existing, sometimes very long, indels), I presume that certain current results would ultimately be invalidated (bad alignments for example - this should in particular be even more true as we move away, in the Y tree, from the person who served as the basis for the development of the GRCh38 reference).
Cheers,
Ewenn
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Ewenn