No, if you are referring to the System config setting 'PTT as Serial 3', don't use it.? That refers to using the PTT output connector as a second serial port, which is not fully supported and requires hardware jumper changes.
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Just use beta firmware v_007 (just released today), and set "USB serial ports" to 2 or 3, and the additional com ports will appear on your computer via the USB cable.
