Scott, in general, applications will be slightly different, but will fall into a handful of approaches.
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For example, in my repeater application, I have oscillator modules using a FET. I will remove the crystal and the feedback in the oscillator circuit, replace the crystal with a progrock2, and use the former oscillator as a buffer. It's possible to replace both oscillators with a single progrock2, but in this case, I want to remain compatible with the original design, since the repeater can use eight selectable oscilator pairs. I have 10VDC available for power.
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For my Atlas, I plan to use a singe progrock2 directly for three of the ten user selectable band segments, directly replacing three crystals. I have 7.5VDC power there.
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Without seeing the inside of your radio and a schematic of the oscillator section, all I can say is your solution might resemble one of the above. Padding, filtering, and power are the things that can complicate basic replacement.
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The datasheet for the SI5351A will show other possibilities. It's a good starting point.
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73 Chuck AI7SY
Chuck AI7SY