????????? Well damn, what can one do about that?? Might this be due to blood being diverted to the gut to pick up nutrients, dropping pressure in other parts of the body?? Might
it help to eat several small meals rather than a big lunch and a big dinner??
?
Karl L. Wuensch, Professor and ECU Scholar/Teacher, Dept. of Psychology
East Carolina University, Greenville NC? 27858-4353, USA,?
Voice:? 252-328-9420???? Fax:? 252-328-6283
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From: [email protected] < [email protected]> On Behalf Of
ScottishDave via groups.io
Sent: Sunday, January 29, 2023 9:18 PM
To: [email protected]
Subject: Re: [NAION] Blood Pressure
?
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This email originated from outside ECU.
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On Fri, Jan 20, 2023 at 10:26 AM, Wuensch, Karl Louis wrote:
????????? From my readings, the usual causal event is low blood pressure in the anterior optic nerve.? Any association with high blood pressure is likely due to the medications prescribed for high blood pressure lowering blood pressure
at night too much, especially if taken in the evening.
My doctor has just discovered I have a severe, daily drop in blood pressure after eating lunch or dinner. This is known as "postprandial hypotension" and it occurs in 1 in 3 of people over 60 (which I am). My
blood pressure is normal most times including when my doctor has taken my BP in the past. I asked him if this could have been a contributing factor to my NAION and he said perhaps.
I'm seeing my doctor next week to investigate this further.
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On Fri, Jan 20, 2023 at 10:26 AM, Wuensch, Karl Louis wrote:
????????? From my readings, the usual causal event is low blood pressure in the anterior optic nerve.? Any association with high blood pressure is likely due to the medications prescribed for high blood pressure lowering blood pressure at night too much, especially if taken in the evening.
My doctor has just discovered I have a severe, daily drop in blood pressure after eating lunch or dinner. This is known as "postprandial hypotension" and it occurs in 1 in 3 of people over 60 (which I am). My blood pressure is normal most times including when my doctor has taken my BP in the past. I asked him if this could have been a contributing factor to my NAION and he said perhaps. I'm seeing my doctor next week to investigate this further.
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????????? From my readings, the usual causal event is low blood pressure in the anterior optic nerve.? Any association with high blood pressure is likely due to the medications
prescribed for high blood pressure lowering blood pressure at night too much, especially if taken in the evening.
?
Karl L. Wuensch, Professor and ECU Scholar/Teacher, Dept. of Psychology
East Carolina University, Greenville NC? 27858-4353, USA,?
Voice:? 252-328-9420???? Fax:? 252-328-6283
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From: [email protected] < [email protected]> On Behalf Of
Paula Mcglasson via groups.io
Sent: Thursday, January 19, 2023 5:41 PM
To: [email protected]
Subject: Re: [NAION] Ischemic optic neuropathy
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This email originated from outside ECU.
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Nope...I was under a lot of stress but no high blood pressure or anemia.
?
On Thu, Jan 19, 2023 at 5:38 PM Bobbie James <rrjames61@...> wrote:
Nope.? Apparently I was perfectly healthy when this happened to me...all tests negative, etc.? Just potentially bad anatomy.?
?
On Thu, Jan 19, 2023, 3:19 PM Medi Far <f.far977@...> wrote:
Most of you have anemia and low blood pressure. Is it true?
--
Professor Paula McGlasson?? She, Her, Hers
Production Manager, URI Theatre
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Re: Ischemic optic neuropathy
Ischemia is lack of or lessening of blood flow. ?Blood provides oxygen to cells therefore if you starve a cell or neuron in our case of blood long enough the risk of neuropathy (death of the neuron) increases. ?Theories are that low blood pressure complicated by sleep apnea are of high potential to cause NAION. ?Anemia can also assist, if you will in causing ischemia as it robs the blood of its oxygen carrying ability. ?In all of our cases, no one knows exactly what actually caused our neuropathy. ?All we truly have are scholarly guesses. ?
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Re: Ischemic optic neuropathy
No blood pressure issues or anemia here mine happened pretty soon after I got out of the hospital for severe case of covid so my theory is something to do with the low blood oxygen I was experiencing for over a week.
On Thu, Jan 19, 2023, 3:19 PM Medi Far < f.far977@...> wrote: Most of you have anemia and low blood pressure. Is it true?
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Re: Ischemic optic neuropathy
Nope...I was under a lot of stress but no high blood pressure or anemia.
Paula
On Thu, Jan 19, 2023 at 5:38 PM Bobbie James < rrjames61@...> wrote: Nope.? Apparently I was perfectly healthy when this happened to me...all tests negative, etc.? Just potentially bad anatomy.?
On Thu, Jan 19, 2023, 3:19 PM Medi Far < f.far977@...> wrote: Most of you have anemia and low blood pressure. Is it true?
-- Professor Paula McGlasson?? She, Her, Hers
Production Manager, URI Theatre (401) 874-2712 office (401) 315-2227 home (401) 743-1039 cell
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Re: Ischemic optic neuropathy
Nope.? Apparently I was perfectly healthy when this happened to me...all tests negative, etc.? Just potentially bad anatomy.?
On Thu, Jan 19, 2023, 3:19 PM Medi Far < f.far977@...> wrote: Most of you have anemia and low blood pressure. Is it true?
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Sleep Apnea is only one of the many factors for NAION. I just happened to have this occur to me?
On Fri, 20 Jan 2023 at 8:35 am, Marc Gold < marcgold@...> wrote: Sorry that’s incorrect. Most NAION victims do NOT have sleep apnea.
Marc
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Re: Ischemic optic neuropathy
Hi Deane. Yes. My blood pressure has been on the lower to normal side. I am a vegetarian so had lower iron levels. My blood pressure dropped too low during the night and my optic nerve was starved if oxygen due to Slepp Apnea?
On Fri, 20 Jan 2023 at 9:21 am, Deane Williams < pyroartist@...> wrote:
No anemia, BP was always on the low side but
normal.
On 1/19/2023 3:19 PM, Medi Far wrote:
Most of you have anemia and low blood pressure. Is it true?
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Re: Ischemic optic neuropathy
No anemia, BP was always on the low side but
normal.
On 1/19/2023 3:19 PM, Medi Far wrote:
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Most of you have anemia and low blood pressure. Is it true?
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Re: Ischemic optic neuropathy
No anemia or hypotension, just recently diagnosed with sleep apnea which (per a recent Eyewiki article) is "associated with NAION although in all of the cases, no causal relationship has been definitely established".? ? Probably not new information for most of the group but thought I would share for the newer members.? ?I just started this journey in November 2022.? ?
Here's the link.? ?
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Oh really? I’m sorry if I spoke misinformed. We’ve been on this journey since June 2022 so still fairly new. This is what we’ve been told thus far including at Houston methodist with Dr. Lee. ???♀?
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On Jan 19, 2023, at 2:35 PM, Marc Gold <marcgold@...> wrote:
?Sorry that’s incorrect. Most NAION victims do NOT have sleep apnea.
Marc
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Sorry that’s incorrect. Most NAION victims do NOT have sleep apnea.
Marc
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Re: Ischemic optic neuropathy
No anemia. Just low blood pressure at night when diagnosed. Lowered the blood pressure medicine and it fixed the problem. Also have sleep apnea which is common among NAION patients.?
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On Jan 19, 2023, at 1:45 PM, Medi Far <f.far977@...> wrote:
?Most of you have anemia and low blood pressure. Is it true?
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Re: Ischemic optic neuropathy
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-------- Original message -------- From: Marc Gold <marcgold@...> Date: 1/19/23 12:47 PM (GMT-08:00) Subject: Re: [NAION] Ischemic optic neuropathy
Not me. I have always had normal blood pressure and I have never been anemic.
Marc On Thu, Jan 19, 2023 at 3:19 PM Medi Far < f.far977@...> wrote: Most of you have anemia and low blood pressure. Is it true?
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Re: Ischemic optic neuropathy
Not me. I have always had normal blood pressure and I have never been anemic.
Marc
On Thu, Jan 19, 2023 at 3:19 PM Medi Far < f.far977@...> wrote: Most of you have anemia and low blood pressure. Is it true?
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Ischemic optic neuropathy
Most of you have anemia and low blood pressure. Is it true?
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Re: Good news towards retina regrowth!
this is wonderful news.? I hope there is some success with Stem Cell research and stimulating or regrowing optic nerve damage in our case.?
On Tue, Jan 10, 2023 at 7:09 AM Deane Williams < pyroartist@...> wrote:
From a January 4th paper comes good news
towards eye regeneration.
They do not specifically mention the optic nerve but they may
be working towards that as they mention glaucoma.
We may be another step closer.
Dean
As we mammals get
older, many?of us start to lose our eyesight because the
neurons in our retinas degenerate.? Our retinal ganglion
cells might get attacked by glaucoma, or our rods and
cones (photoreceptors) might get eroded by macular
degeneration or retinitis pigmentosa.? Somewhere in the
course of evolution, we lost our ability to regenerate
those kinds of cells, just like we lost the ability to
regenerate limbs.? Once they’re gone, they’re gone.
But we humans did develop some other things really
well:?the ability to use reason and the desire to
sustain ourselves.? And those attributes have brought us
to the verge of making up for some of our evolutionary
shortcomings.?
It’s amazing enough that
grow human stem cells into retinal “organoids” —?little
balls that
all the different types of cells it takes to make a
functioning retina, even organized into the right
layers.
But now we’ve?learned that if we break up the organoid
into individual cells, those cells are?capable of
spontaneously forming signal-communicating connections ()?with
other retinal cells.? That means that a patient could
have their own stem cells grown into retinal cells and
applied to their own retina, these new cells could
functionally replace the old, and vision could be
restored.? No gene therapy required, thanks very much.
You can read all about this last hurdle being
at the University of Wisconsin labs of Drs. David Gamm
and Xinyu Zhao in the
January 4 issue of the Proceedings of the
National Academy of Sciences.
For more info with diagrams and pictures:
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Re: Good news towards retina regrowth!
Thanks for the details, Adam.
Diane Keasler
Life is the school, love is the lesson.
On Tuesday, January 10, 2023 at 08:38:41 PM EST, Amy + Adam via groups.io <alf.acs@...> wrote:
While this is a nice result, I do not think it is yet on a path for human trials. Organoids are really useful for studying normal development. Previously it was shown that retinal organoids make three cell types that are in a retina. Here they show that these cell types connect to each other. ? But this is still very far away from being an operational retina. Real retinas have specific connections between the photoreceptors and multiple types of interneurons; the interneurons in turn have complex connections to each other, and to the retinal ganglion cells. ? In addition, it is a big problem to get the retinal ganglion cells to grow axons far into the brain to make the right connections. That is not addressed in this paper at all.? Also, we NIAON folk are missing some of our retinal ganglion cells—I think we still have the interneurons and photoreceptors. ?? ? Finally, it is probably not wise to inject human embryonic stem cells into people. For one thing, they are from another person (immune response) For another, they are designed to have a lot of developmental plasticity (so you have to worry about them differentiating into unwanted cell types, including cancer). ? So while this shows that retinal organoids are a good system for learning about normal development, this is still very far from a therapy. ? Please think very carefully before participating in stem cell clinical trials. There is a bad history here, for eye disease in particular. ? ? Adam ?
From: [email protected] < [email protected]> On Behalf Of Deane Williams Sent: Monday, January 09, 2023 8:54 PM To: [email protected]Subject: Re: [NAION] Good news towards retina regrowth! ? No, not available. Maybe human trials in the next few years. On 1/9/2023 8:46 PM, carlo maglione via groups.io wrote: So where can I have this done? Is this treatment available at this time?
On Monday, January 9, 2023, 12:09 PM, Deane Williams <pyroartist@...> wrote: From a January 4th paper comes good news towards eye regeneration.
They do not specifically mention the optic nerve but they may
be working towards that as they mention glaucoma.
We may be another step closer.
Dean As we mammals get older, many?of us start to lose our eyesight because the neurons in our retinas degenerate.? Our retinal ganglion cells might get attacked by glaucoma, or our rods and cones (photoreceptors) might get eroded by macular degeneration or retinitis pigmentosa.? Somewhere in the course of evolution, we lost our ability to regenerate those kinds of cells, just like we lost the ability to regenerate limbs.? Once they’re gone, they’re gone. But we humans did develop some other things really well:?the ability to use reason and the desire to sustain ourselves.? And those attributes have brought us to the verge of making up for some of our evolutionary shortcomings.? It’s amazing enough that grow human stem cells into retinal “organoids” —?little balls that all the different types of cells it takes to make a functioning retina, even organized into the right layers. But now we’ve?learned that if we break up the organoid into individual cells, those cells are?capable of spontaneously forming signal-communicating connections ()?with other retinal cells.? That means that a patient could have their own stem cells grown into retinal cells and applied to their own retina, these new cells could functionally replace the old, and vision could be restored.? No gene therapy required, thanks very much. You can read all about this last hurdle being at the University of Wisconsin labs of Drs. David Gamm and Xinyu Zhao in the January 4 issue of the Proceedings of the National Academy of Sciences. For more info with diagrams and pictures:
?
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GaryGBrown