Ischemia is lack of or lessening of blood flow. ?Blood provides oxygen to cells therefore if you starve a cell or neuron in our case of blood long enough the risk of neuropathy (death of the neuron) increases. ?Theories are that low blood pressure complicated by sleep apnea are of high potential to cause NAION. ?Anemia can also assist, if you will in causing ischemia as it robs the blood of its oxygen carrying ability. ?In all of our cases, no one knows exactly what actually caused our neuropathy. ?All we truly have are scholarly guesses. ?