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Yes, it is true in mice but there are many problems in duplicating this in humans. Dr. Sinclair is well known as a sensationalist.
That is how he sells books. The method he is talking about is the use of 4 compounds known as the Yamanaka Factors. (Google it.)
The 4 are abbreviated as O,K,S and M.
Here is a brief summary of the problems that are encountered when trying to use this in humans from another expert in this field:

Aubrey de Grey: The problem is that OKSM doesn't only eliminate noise - it eliminates (very nearly) all epigenetic marks, whether noise or signal. The only reason it can be therapeutic is because doing just a little bit of that wiping of information seems to be OK - the cell can use the residual signal as a guide to rebuild the lost signal, whereas the proportion of the noise that was also removed is really gone. Sounds good! Except ... that in the body (even the young adult) there are a lot of cells that are most of the way to becoming cancerous. These cells are in what we can think of as an epigenetically fragile state: it doesn't take much to tip them over the edge, because their cell-cycle stabilisation defences are already damaged. So, all in all, I am currently quite pessimistic about the future of OKSM-based rejuvenation.