Only one can use a port at a time.? Com0Com creates virtual port pairs, for example #40 & #41.? Each program would need to use the second port in the pair.? The second one sends to the first one which is what Com0Com sees and sends to the control program.
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Here's how mine is setup
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Radio physically connected to the computer running 101Cats (control program for FTDX101).?? 101Cats is designed to work with virtual port programs (like Win4Yaesu or Win4Icom is).? Com0Com created six virutal port pairs for me.? I can run WSJT, FLDigi, Winlink, JS8Call and others at the same time.? Each program is configured for its own virtual port, so there is no "port in use" conflict.
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Hope that makes sense,
Ryan
KI6BTY
Ryan Huggins