Hey Luca,
I have never used an iOptron mount. I was thinking about a CEM70 at one point and opted for the G11 and I haven't looked back. I agree with all of Chip's points.
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As far as cable management goes, I use a mount-side NUC computer to run all mount control software with a Pegasus Powerbox to control mount and USB. I have a single power cable and a single USB cable to the Powerboat. These cables are routed through sleeves to give them some shape/stiffness. They float outside the motion of the mount and do not catch on the mount at any position in the range of motion. For me, this is as effective as any through-the-mount cabling could be.
as for guiding accuracy, this is what is possible (see below) after learning how to adjust your mount appropriately ?and utilizing PEC. Chip's guiding figures are realistic but consider that he is an expert operator who has finely tuned his craft. I would wager that you could at least match a CEM70 performance with guiding and then add that a G11 is meant to be user serviceable, as compared to a CEM70 or other iOptron mount which would be meant to be sent back to the manufacturer for any service.
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The Losmandy mount is a lifetime mount. It is a user-serviceable workhorse with the associated learning curve. In my humble opinion, owning a Losmandy mount requires a modicum of confidence and desire to learn how to care-for and feed it. If you have those traits, I would imagine you will do just fine.
Ryan Noonan