You'd have to run a Windows emulator.
The program changes the 50 ohm reference impedance to the impedance you specify. For example, if you set the renormalization impedance to 1.5k ohms, the renormalized |S21| response of a filter will be as if had you driven and loaded it with 1.5k. If you measure a device using an impedance it's not designed for, you won't get the response it would exhibit in a circuit that uses the proper impedances. The program lets you see the correct response without actually driving/loading the device with the proper impedance.
The attached plot shows the response of a Murata 10.7 MHz ceramic filter. The blue curve is |S21| for the 50 ohm VNA measurement. The red curve is after the data was renormalized to 330 ohms, which is the source/load impedance the filter was designed for. The renormalized response is as expected.
Brian