With the Prologix you must use FTDI to enumerate your serial port. EZGPIB works extremely well. The learning curve was one day. Ulrich did a wonderful job developing it. I like Python a lot. Maybe get stuff talking with EZGPIB then use instrument specific language
to write in another language.
I wrote a bunch of EZGPIB programs at Tektronix. It can get as sophisticated as one wants...
Steve
KG7HYG