I also see the S-meter sticking sometimes on my V4 with 1.100 software and a Nextion V3 panel, and that happens inconsistently from time to time when executing other options and not just the step change. If I select "Lock" then "unLock" it seems to release something and the meter returns to normal operation , but even that isn't always immediately true. This happened with just using a small audio amp feeding the spare input for an S-meter, which I was able to calibrate pretty well to match other rigs using the Memory Manager table.
Since then I added the second I2C-connected arduino and changed to the DSP meter. The calibration (not available through MM) was pretty far off as installed, so I went into the sketch and modified the level thresholds there and it seems pretty good, now. However, I do have an issue with this 2-processor setup. From time to time, usually when selecting either spectrum or CW decode options, but at least once with neither selected, it will lock the rig in transmit. for example, I might be manually accessing a slider to adjust scan across the band and I get a tone as if a CW key was depressed, but the rig is otherwise unresponsive to inputs until I cycle the power. After turning off and back on again, it returns to normal. I suspect this is just a glitch in the processing, sort of a "Nextion thing" as you describe, but something to watch. It never happened before chaining the second arduino, though.
=Vic=