I just experimented with the
ClockBuilder Pro software. It does not like the SI5351 with 3
outputs and provides warnings under all conditions that I tested.
I tried everything I could think of. I switched to the 8 clock
output version, and using clocks 0, 2 and 4 it is happy. So my
recommendation would be to change to the SI5351ABGM. The clocks
should then be much cleaner.