Crestron doesn't like high DPI displays no matter what, even on pure Windows. This is a Crestron issue, not a MAC issue.
Running something in compatibility mode often helps for this. Right click the executable, select the Compatibility tab, and check "Disable display scaling on high DPI settings". But it would be nice if Crestron tested their stuff on high res displays, as these are becoming more and more common (but absolutely not the "norm" yet).
As for Windows 10 compatibility in general, I had problems with MasterInstaller with technical previews of Windows 10. But since the final release, MasterInstaller works fine for me, both for upgrades from Windows 8.1 and for fresh installs.
/Jeff
