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Hi folks,

Happy New Year!

I'm writing to get a head start on collecting BAM (Binary Alignment Map) files for an upcoming migration of the YDNA Warehouse tree to the hs1 reference genome in 2025. This update aligns with the data from the experimental group of R1b-FGC11134 samples currently in progress.

For most of you who have already provided a BAM, no further action is required. I'll process your data once I'm finished addressing DE and IJ subclades.

If you haven't provided a BAM or have upgraded to Big Y 700 since then, here's why submitting a current BAM is beneficial:

• Smoother data realignment: Distributing submissions throughout this time will help with the realignment process to hs1. Registered members will receive a notification from info@... when it's crunch time to submit.
• Updated Big Y STR Panels: This is an opportunity to update your Big Y STR panels, which you can compare with others in the (enrollment or investigator access required).
• More precise tree inference: Upgraders, your additional ~5 million bases will significantly improve the accuracy of the tree.

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Privacy Considerations:

• Your data security is our top priority. We employ robust technological safeguards and offer optional 2-factor authentication for your account.
• All data shared publicly is completely de-identified. We use new kit numbers (Taxon IDs) and allow you to control the information displayed in reports (e.g., EKA details, kit aliases).

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Alternative File Formats:

If your lab charges extra for BAM files, VCF or BED formats are acceptable. However, integrating these files into the final tree position will require manual processing, which is currently backlogged for branches outside of mine. I'm finalizing tools to streamline this process in the future.

You’re Not R-U106:

Feel free to also start updating your files and sharing with your more specific subclade.? I’m starting with U106 when coming back to R1b, since it’s currently the furthest behind in updates.

Thanks for your time and participation!

James Kane

James,
Happy New Year and a big thanks for all your hard work.