The only things lost by not doing calibration are:
1) the phase pre-distortion compensation doesn't do anything (as if you had turned it off)
2) the sideband phase/amplitude synchronization is set to mid-level (50) for all bands, which on average is a reasonably good setting, vs. getting a custom value for each band.
Both of these are intended to decrease the IMD3 distortion products below its already reasonably good performance.
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All other SSB functionality is completely functional without calibration, including CESSB, compression, mic equalization, mic agc, mic noise gating, and amplitude pre-distortion compensation.
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Stan KC7XE