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NAION CLINICAL REPORT BY GOOGLE GROK


 


There are a few ongoing and completed clinical trials exploring various treatments for NAION (non-arteritic anterior ischemic optic neuropathy). These trials investigate different approaches, including intravitreal injections of stem cells, anti-VEGF agents, and surgical interventions, with the goal of improving visual function and safety. [, , ]

Ongoing and Completed Trials: [, , ]
  • Intravitreal Injections: Some trials are focused on intravitreal injections of different substances, such as allogeneic bone marrow-derived mesenchymal stem cells (BM-MSCs), or anti-VEGF agents like ranibizumab or bevacizumab. These injections aim to target the optic nerve and retina, potentially improving vision or reducing the risk of further damage. [, , ]
  • Surgical Interventions: While the Ischemic Optic Neuropathy Decompression Trial (IONDT) found no benefit from surgical intervention, some researchers are still exploring surgical options like optic nerve decompression, transvitreal optic neurotomy, and pars plana vitrectomy. [, ]
  • Other Therapies: Some trials are investigating the use of oral steroids, and others are exploring the potential benefits of platelet-rich plasma (PRP) injections. [, ]
Example Trials: []
  • A Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION): This trial, conducted at Stanford Medicine, investigates the effect of QPI-1007 on visual function and safety in patients with NAION. []
  • A Non-Randomized Phase II Clinical Trial for Acute Non-Arteritic Optic Neuropathy: This trial explored the use of allogeneic BM-MSCs through intravitreal injection in patients with NAION. []
  • A Randomized Controlled Phase 2a Study of RPh201 in Previous Nonarteritic Anterior Ischemic Optic Neuropathy: This study investigated the safety and efficacy of RPh201 in patients with previous NAION. []

Generative AI is experimental.
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Stanford is doing a study on TES electrical stimulation, but it is for glaucoma patients for vision loss.

On Apr 14, 2025, at 4:03?PM, Russ Poter via groups.io <russpoter@...> wrote:

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There are a few ongoing and completed clinical trials exploring various treatments for NAION (non-arteritic anterior ischemic optic neuropathy). These trials investigate different approaches, including intravitreal injections of stem cells, anti-VEGF agents, and surgical interventions, with the goal of improving visual function and safety. [, , ]

Ongoing and Completed Trials: [, , ]
  • Intravitreal Injections: Some trials are focused on intravitreal injections of different substances, such as allogeneic bone marrow-derived mesenchymal stem cells (BM-MSCs), or anti-VEGF agents like ranibizumab or bevacizumab. These injections aim to target the optic nerve and retina, potentially improving vision or reducing the risk of further damage. [, , ]
  • Surgical Interventions: While the Ischemic Optic Neuropathy Decompression Trial (IONDT) found no benefit from surgical intervention, some researchers are still exploring surgical options like optic nerve decompression, transvitreal optic neurotomy, and pars plana vitrectomy. [, ]
  • Other Therapies: Some trials are investigating the use of oral steroids, and others are exploring the potential benefits of platelet-rich plasma (PRP) injections. [, ]
Example Trials: []
  • A Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION): This trial, conducted at Stanford Medicine, investigates the effect of QPI-1007 on visual function and safety in patients with NAION. []
  • A Non-Randomized Phase II Clinical Trial for Acute Non-Arteritic Optic Neuropathy: This trial explored the use of allogeneic BM-MSCs through intravitreal injection in patients with NAION. []
  • A Randomized Controlled Phase 2a Study of RPh201 in Previous Nonarteritic Anterior Ischemic Optic Neuropathy: This study investigated the safety and efficacy of RPh201 in patients with previous NAION. []

Generative AI is experimental.
[1]?
[2]?
[3]?
[4]?
[5]?
[6]?
[-]?
[-]?