Re: Immunotherapy induced NAION
Hello,? Yes, please share which?Dermatological immunotherapy you used. A few weeks ago, I?completed a 12-day round of?Fluorouracil topical 5% that my NO pre-approved. I have not noticed any vision change, but my migraines have returned. Thank you,
Do you know the cream you were prescribed? I was just prescribed SLUOROURACIL and CALCIPOTRIENE.
I was chatting to my neuro-opthamologist about the possibility of my past immunotherapy treatment (for skin precancers) causing my NAION. He said it was a strong possibilty although he has no evidence of it being the cause.?
I was using a topical immunotherapy ointment which raises the level of beta interferon levels in the body. The theory is that the higher levels of interferon leads to the immune system putting down deposits in the optic nerve.
In doing some research myself I came across a couple of articles.
Ocular side effects of biological agents in oncology: what should the clinician be aware of?
Ocular side effects of novel anti-cancer biological therapies
Has anybody else had immunotherapy and developed NAION shortly after?
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Re: Immunotherapy induced NAION
Do you know the cream you were prescribed? I was just prescribed SLUOROURACIL and CALCIPOTRIENE.
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On Sep 26, 2022, at 6:48 PM, ScottishDave <scottishdave@...> wrote:
I was chatting to my neuro-opthamologist about the possibility of my past immunotherapy treatment (for skin precancers) causing my NAION. He said it was a strong possibilty although he has no evidence of it being the cause.?
I was using a topical immunotherapy ointment which raises the level of beta interferon levels in the body. The theory is that the higher levels of interferon leads to the immune system putting down deposits in the optic nerve.
In doing some research myself I came across a couple of articles.
Ocular side effects of biological agents in oncology: what should the clinician be aware of?
Ocular side effects of novel anti-cancer biological therapies
Has anybody else had immunotherapy and developed NAION shortly after?
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????????? Well damn, what can one do about that?? Might this be due to blood being diverted to the gut to pick up nutrients, dropping pressure in other parts of the body?? Might
it help to eat several small meals rather than a big lunch and a big dinner??
?
Karl L. Wuensch, Professor and ECU Scholar/Teacher, Dept. of Psychology
East Carolina University, Greenville NC? 27858-4353, USA,?
Voice:? 252-328-9420???? Fax:? 252-328-6283
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From: [email protected] < [email protected]> On Behalf Of
ScottishDave via groups.io
Sent: Sunday, January 29, 2023 9:18 PM
To: [email protected]
Subject: Re: [NAION] Blood Pressure
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This email originated from outside ECU.
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On Fri, Jan 20, 2023 at 10:26 AM, Wuensch, Karl Louis wrote:
????????? From my readings, the usual causal event is low blood pressure in the anterior optic nerve.? Any association with high blood pressure is likely due to the medications prescribed for high blood pressure lowering blood pressure
at night too much, especially if taken in the evening.
My doctor has just discovered I have a severe, daily drop in blood pressure after eating lunch or dinner. This is known as "postprandial hypotension" and it occurs in 1 in 3 of people over 60 (which I am). My
blood pressure is normal most times including when my doctor has taken my BP in the past. I asked him if this could have been a contributing factor to my NAION and he said perhaps.
I'm seeing my doctor next week to investigate this further.
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On Fri, Jan 20, 2023 at 10:26 AM, Wuensch, Karl Louis wrote:
????????? From my readings, the usual causal event is low blood pressure in the anterior optic nerve.? Any association with high blood pressure is likely due to the medications prescribed for high blood pressure lowering blood pressure at night too much, especially if taken in the evening.
My doctor has just discovered I have a severe, daily drop in blood pressure after eating lunch or dinner. This is known as "postprandial hypotension" and it occurs in 1 in 3 of people over 60 (which I am). My blood pressure is normal most times including when my doctor has taken my BP in the past. I asked him if this could have been a contributing factor to my NAION and he said perhaps. I'm seeing my doctor next week to investigate this further.
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????????? From my readings, the usual causal event is low blood pressure in the anterior optic nerve.? Any association with high blood pressure is likely due to the medications
prescribed for high blood pressure lowering blood pressure at night too much, especially if taken in the evening.
?
Karl L. Wuensch, Professor and ECU Scholar/Teacher, Dept. of Psychology
East Carolina University, Greenville NC? 27858-4353, USA,?
Voice:? 252-328-9420???? Fax:? 252-328-6283
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From: [email protected] < [email protected]> On Behalf Of
Paula Mcglasson via groups.io
Sent: Thursday, January 19, 2023 5:41 PM
To: [email protected]
Subject: Re: [NAION] Ischemic optic neuropathy
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This email originated from outside ECU.
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Nope...I was under a lot of stress but no high blood pressure or anemia.
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On Thu, Jan 19, 2023 at 5:38 PM Bobbie James <rrjames61@...> wrote:
Nope.? Apparently I was perfectly healthy when this happened to me...all tests negative, etc.? Just potentially bad anatomy.?
?
On Thu, Jan 19, 2023, 3:19 PM Medi Far <f.far977@...> wrote:
Most of you have anemia and low blood pressure. Is it true?
--
Professor Paula McGlasson?? She, Her, Hers
Production Manager, URI Theatre
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Re: Ischemic optic neuropathy
Ischemia is lack of or lessening of blood flow. ?Blood provides oxygen to cells therefore if you starve a cell or neuron in our case of blood long enough the risk of neuropathy (death of the neuron) increases. ?Theories are that low blood pressure complicated by sleep apnea are of high potential to cause NAION. ?Anemia can also assist, if you will in causing ischemia as it robs the blood of its oxygen carrying ability. ?In all of our cases, no one knows exactly what actually caused our neuropathy. ?All we truly have are scholarly guesses. ?
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Re: Ischemic optic neuropathy
No blood pressure issues or anemia here mine happened pretty soon after I got out of the hospital for severe case of covid so my theory is something to do with the low blood oxygen I was experiencing for over a week.
On Thu, Jan 19, 2023, 3:19 PM Medi Far < f.far977@...> wrote: Most of you have anemia and low blood pressure. Is it true?
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Re: Ischemic optic neuropathy
Nope...I was under a lot of stress but no high blood pressure or anemia.
Paula
On Thu, Jan 19, 2023 at 5:38 PM Bobbie James < rrjames61@...> wrote: Nope.? Apparently I was perfectly healthy when this happened to me...all tests negative, etc.? Just potentially bad anatomy.?
On Thu, Jan 19, 2023, 3:19 PM Medi Far < f.far977@...> wrote: Most of you have anemia and low blood pressure. Is it true?
-- Professor Paula McGlasson?? She, Her, Hers
Production Manager, URI Theatre (401) 874-2712 office (401) 315-2227 home (401) 743-1039 cell
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Re: Ischemic optic neuropathy
Nope.? Apparently I was perfectly healthy when this happened to me...all tests negative, etc.? Just potentially bad anatomy.?
On Thu, Jan 19, 2023, 3:19 PM Medi Far < f.far977@...> wrote: Most of you have anemia and low blood pressure. Is it true?
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Sleep Apnea is only one of the many factors for NAION. I just happened to have this occur to me?
On Fri, 20 Jan 2023 at 8:35 am, Marc Gold < marcgold@...> wrote: Sorry that’s incorrect. Most NAION victims do NOT have sleep apnea.
Marc
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Re: Ischemic optic neuropathy
Hi Deane. Yes. My blood pressure has been on the lower to normal side. I am a vegetarian so had lower iron levels. My blood pressure dropped too low during the night and my optic nerve was starved if oxygen due to Slepp Apnea?
On Fri, 20 Jan 2023 at 9:21 am, Deane Williams < pyroartist@...> wrote:
No anemia, BP was always on the low side but
normal.
On 1/19/2023 3:19 PM, Medi Far wrote:
Most of you have anemia and low blood pressure. Is it true?
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Re: Ischemic optic neuropathy
No anemia, BP was always on the low side but
normal.
On 1/19/2023 3:19 PM, Medi Far wrote:
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Most of you have anemia and low blood pressure. Is it true?
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Re: Ischemic optic neuropathy
No anemia or hypotension, just recently diagnosed with sleep apnea which (per a recent Eyewiki article) is "associated with NAION although in all of the cases, no causal relationship has been definitely established".? ? Probably not new information for most of the group but thought I would share for the newer members.? ?I just started this journey in November 2022.? ?
Here's the link.? ?
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Oh really? I’m sorry if I spoke misinformed. We’ve been on this journey since June 2022 so still fairly new. This is what we’ve been told thus far including at Houston methodist with Dr. Lee. ???♀?
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On Jan 19, 2023, at 2:35 PM, Marc Gold <marcgold@...> wrote:
?Sorry that’s incorrect. Most NAION victims do NOT have sleep apnea.
Marc
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Sorry that’s incorrect. Most NAION victims do NOT have sleep apnea.
Marc
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Re: Ischemic optic neuropathy
No anemia. Just low blood pressure at night when diagnosed. Lowered the blood pressure medicine and it fixed the problem. Also have sleep apnea which is common among NAION patients.?
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On Jan 19, 2023, at 1:45 PM, Medi Far <f.far977@...> wrote:
?Most of you have anemia and low blood pressure. Is it true?
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Re: Ischemic optic neuropathy
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-------- Original message -------- From: Marc Gold <marcgold@...> Date: 1/19/23 12:47 PM (GMT-08:00) Subject: Re: [NAION] Ischemic optic neuropathy
Not me. I have always had normal blood pressure and I have never been anemic.
Marc On Thu, Jan 19, 2023 at 3:19 PM Medi Far < f.far977@...> wrote: Most of you have anemia and low blood pressure. Is it true?
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Re: Ischemic optic neuropathy
Not me. I have always had normal blood pressure and I have never been anemic.
Marc
On Thu, Jan 19, 2023 at 3:19 PM Medi Far < f.far977@...> wrote: Most of you have anemia and low blood pressure. Is it true?
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Ischemic optic neuropathy
Most of you have anemia and low blood pressure. Is it true?
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GaryGBrown