Re: Semaglutide and NAION
Hi Marc,
Thanks for your post. I feel obligated to let you know that I was in your shoes not too long ago (March 2024) and unfortunately suffered from a second NAION in my neighboring eye after using a GLP (Mounjorno) for approximately 6 months. I completely understand the risk vs. benefit ratio and that the improvements from weight loss, etc. are tremendous but I have to say that the potential loss of vision in both eyes is devastating. Once you have a NAION in both eyes, there may be significant blind spots based on the areas between your two eyes that overlap and therefore have true total vision loss (when there is only one eye involved, the neighboring eye compensates to the point where you don't notice the vision loss). I'm not suggesting that you change your opinion / plan, rather, just be sure that you can't control your diabetes, etc. through diet, other medications, etc. to try to prevent an ischemic event from GLP induced decreased blood flow. Also, do you have crowded disc syndrome (small cup to disc ratio in both eyes)? As you know, once it occurs, you can't reverse it. I've been seeing a neuro-ophthalmologist at Mass Eye and Eye who has been researching and publishing on the association between NAION and GLPs. Please google Dr. Rizzo at Mass General Hospitals and NAION to learn more. Happy to discuss more Marc (and anyone else in this group) to share my experience - once you have a second NAION, the game changes significantly. Thanks.
George ?
On Sunday, March 16, 2025 at 10:57:23 PM EDT, Marc Gold via groups.io <marcgold@...> wrote:
The evidence of a link between Semaglutide and NAION is indeed very weak. I already have NAION in one eye.? The improvement of my diabetes, weight, heart and kidney status worries me far more than the small chance my other eye could be affected by Ozempic. I start Ozempic next week @ 1 mg. per week. My physician concurs that the benefits far outweigh the risks. I'll take my chances, which are not high at all: Even though we have demonstrated a higher risk of NAION in persons with T2D exposed to once-weekly semaglutide, it is important to keep in mind that use of semaglutide comes with substantial advantages for patients as given by the improved glycemic control, reduction in risk of cardiovascular disease as well as the beneficial effects of weight loss [1]. As such, the observed incidence rate of NAION of 0¡¤228 per 1000 person-years for persons with T2D exposed with once-weekly semaglutide may not discourage semaglutide treatment but needs to be acknowledged as a potential risk. This is truly a miracle drug in the same way that penicillin, statin drugs, Covid vaccines, insulin and Sildenafil have demonstrated. We are lucky to live in this age of pharmaceutical advances and wonders.
I will report my progress which should allay some of your concerns about?Semaglutide and NAION.
Marc
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The evidence of a link between Semaglutide and NAION is indeed very weak. I already have NAION in one eye.? The improvement of my diabetes, weight, heart and kidney status worries me far more than the small chance my other eye could be affected by Ozempic. I start Ozempic next week @ 1 mg. per week. My physician concurs that the benefits far outweigh the risks. I'll take my chances, which are not high at all: Even though we have demonstrated a higher risk of NAION in persons with T2D exposed to once-weekly semaglutide, it is important to keep in mind that use of semaglutide comes with substantial advantages for patients as given by the improved glycemic control, reduction in risk of cardiovascular disease as well as the beneficial effects of weight loss [1]. As such, the observed incidence rate of NAION of 0¡¤228 per 1000 person-years for persons with T2D exposed with once-weekly semaglutide may not discourage semaglutide treatment but needs to be acknowledged as a potential risk. This is truly a miracle drug in the same way that penicillin, statin drugs, Covid vaccines, insulin and Sildenafil have demonstrated. We are lucky to live in this age of pharmaceutical advances and wonders.
I will report my progress which should allay some of your concerns about?Semaglutide and NAION.
Marc
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Re: Semaglutide and NAION
Well, yes! I thought everyone with NAION does to some extent. I was stricken about eight weeks ago. Right eye only, but I¡¯m guessing I¡¯ve lost 90+% of vision. Don¡¯t recognize my wife 3 ft away from me. I have very controlled Type 2 diabetes for which I took relatively low dose of Ozempic (never more than 1 mg) from last August through January of this year. I believe that¡¯s what triggered NAION, but I guess I¡¯ll never know for sure. I have had sleep apnea for 15 years, well controlled and faithful user of CPAP.
Like others commenting here, greatest worry is if it affects other eye, chances of which are raised due to a relatively low disk/cup ratio of 0.25.
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On Mar 15, 2025, at 02:17, Chiarina Blake via groups.io <jc.blake2@...> wrote:
? Hi there and good on you for posting. Yes. I have blurred vision in my only good working eye. Glasses only help to a certain extent. Only slightly. That¡¯s because it¡¯s a brain to eye issue and not a typical refractive issue. It sucks? Have you been tested for sleep Apnea? I got mine because I had severe Sleep Apnea and did nothing about it. Now I use a CPAP machine. If you are overweight like me, sleep apnea is a common cause of NAION.? Take care? On Sat, 15 Mar 2025 at 4:39?am, Dianne Best via <Diannebest31= [email protected]> wrote: Hi
Been following this group a couple of years now; but never posted before. I got NAION in both eyes 2 to 3 years ago. Approx 6 months prior I took Saxenda weight loss injections for about 5 months; stopping about 2 months prior to NAION attack. I only took low doses because they made me feel ill. I do not have diabetes, but was overweight. I am now almost blind in one eye and the other eye is badly affected. My peripheral vision is poor and my vision is permanently blurred. I believe the weight loss drug probably caused the NAION. I have seen a number of articles stating the increase in NAION in people taking these drugs. I thought it important to share this info .
NB does anyone else with NAION have permanently blurred vision?
Thanks
Dianne
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Re: Semaglutide and NAION
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On 15 Mar 2025, at 06:17, Chiarina Blake via groups.io <jc.blake2@...> wrote:
?
Hi there and good on you for posting. Yes. I have blurred vision in my only good working eye. Glasses only help to a certain extent. Only slightly. That¡¯s because it¡¯s a brain to eye issue and not a typical refractive issue. It sucks?
Have you been tested for sleep Apnea? I got mine because I had severe Sleep Apnea and did nothing about it. Now I use a CPAP machine. If you are overweight like me, sleep apnea is a common cause of NAION.?
Take care?
On Sat, 15 Mar 2025 at 4:39?am, Dianne Best via
<Diannebest31= [email protected]> wrote:
Hi
Been following this group a couple of years now; but never posted before. I got NAION in both eyes 2 to 3 years ago. Approx 6 months prior I took Saxenda weight loss injections for about 5 months; stopping about 2 months prior to NAION attack. I only took low
doses because they made me feel ill. I do not have diabetes, but was overweight. I am now almost blind in one eye and the other eye is badly affected. My peripheral vision is poor and my vision is permanently blurred. I believe the weight loss drug probably
caused the NAION. I have seen a number of articles stating the increase in NAION in people taking these drugs. I thought it important to share this info .
NB does anyone else with NAION have permanently blurred vision?
Thanks
Dianne
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Re: Semaglutide and NAION
Hi there and good on you for posting. Yes. I have blurred vision in my only good working eye. Glasses only help to a certain extent. Only slightly. That¡¯s because it¡¯s a brain to eye issue and not a typical refractive issue. It sucks? Have you been tested for sleep Apnea? I got mine because I had severe Sleep Apnea and did nothing about it. Now I use a CPAP machine. If you are overweight like me, sleep apnea is a common cause of NAION.? Take care?
On Sat, 15 Mar 2025 at 4:39?am, Dianne Best via <Diannebest31= [email protected]> wrote: Hi
Been following this group a couple of years now; but never posted before. I got NAION in both eyes 2 to 3 years ago. Approx 6 months prior I took Saxenda weight loss injections for about 5 months; stopping about 2 months prior to NAION attack. I only took low doses because they made me feel ill. I do not have diabetes, but was overweight. I am now almost blind in one eye and the other eye is badly affected. My peripheral vision is poor and my vision is permanently blurred. I believe the weight loss drug probably caused the NAION. I have seen a number of articles stating the increase in NAION in people taking these drugs. I thought it important to share this info .
NB does anyone else with NAION have permanently blurred vision?
Thanks
Dianne
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Re: Semaglutide and NAION
On Fri, Mar 14, 2025 at 1:46?PM Terry Berelowitz via <craigberelowitz= [email protected]> wrote:
Hi
Only one eye affected - lost most of central inferior lateral vision. No contrast no colour intensity. For all purposes, no vision. Live in fear of it happening in my ¡° good¡± eye.? On Fri, 14 Mar 2025 at 19:39, Dianne Best via <Diannebest31= [email protected]> wrote: Hi
Been following this group a couple of years now; but never posted before. I got NAION in both eyes 2 to 3 years ago. Approx 6 months prior I took Saxenda weight loss injections for about 5 months; stopping about 2 months prior to NAION attack. I only took low doses because they made me feel ill. I do not have diabetes, but was overweight. I am now almost blind in one eye and the other eye is badly affected. My peripheral vision is poor and my vision is permanently blurred. I believe the weight loss drug probably caused the NAION. I have seen a number of articles stating the increase in NAION in people taking these drugs. I thought it important to share this info .
NB does anyone else with NAION have permanently blurred vision?
Thanks
Dianne
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Re: Semaglutide and NAION
Hi
Only one eye affected - lost most of central inferior lateral vision. No contrast no colour intensity. For all purposes, no vision. Live in fear of it happening in my ¡° good¡± eye.?
On Fri, 14 Mar 2025 at 19:39, Dianne Best via <Diannebest31= [email protected]> wrote: Hi
Been following this group a couple of years now; but never posted before. I got NAION in both eyes 2 to 3 years ago. Approx 6 months prior I took Saxenda weight loss injections for about 5 months; stopping about 2 months prior to NAION attack. I only took low doses because they made me feel ill. I do not have diabetes, but was overweight. I am now almost blind in one eye and the other eye is badly affected. My peripheral vision is poor and my vision is permanently blurred. I believe the weight loss drug probably caused the NAION. I have seen a number of articles stating the increase in NAION in people taking these drugs. I thought it important to share this info .
NB does anyone else with NAION have permanently blurred vision?
Thanks
Dianne
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Re: Semaglutide and NAION
My vision is permanently blurred but vision was saved severe damage. 20/60 in one eye 20/50 in the other eye.?
I am thankful for that.?
On Fri, Mar 14, 2025 at 1:39?PM Dianne Best via <Diannebest31= [email protected]> wrote: Hi
Been following this group a couple of years now; but never posted before. I got NAION in both eyes 2 to 3 years ago. Approx 6 months prior I took Saxenda weight loss injections for about 5 months; stopping about 2 months prior to NAION attack. I only took low doses because they made me feel ill. I do not have diabetes, but was overweight. I am now almost blind in one eye and the other eye is badly affected. My peripheral vision is poor and my vision is permanently blurred. I believe the weight loss drug probably caused the NAION. I have seen a number of articles stating the increase in NAION in people taking these drugs. I thought it important to share this info .
NB does anyone else with NAION have permanently blurred vision?
Thanks
Dianne
|
Re: Semaglutide and NAION
Hi
Been following this group a couple of years now; but never posted before. I got NAION in both eyes 2 to 3 years ago. Approx 6 months prior I took Saxenda weight loss injections for about 5 months; stopping about 2 months prior to NAION attack. I only took low doses because they made me feel ill. I do not have diabetes, but was overweight. I am now almost blind in one eye and the other eye is badly affected. My peripheral vision is poor and my vision is permanently blurred. I believe the weight loss drug probably caused the NAION. I have seen a number of articles stating the increase in NAION in people taking these drugs. I thought it important to share this info .
NB does anyone else with NAION have permanently blurred vision?
Thanks
Dianne
|
Re: Has anyone tried this item? If yes, is it helpful for people with NAION? I am skeptical.
Awesome. I crochet and think would be convenient?for me ?
On Fri, Mar 14, 2025 at 11:27?AM Pamela Chadick via <apchadick88= [email protected]> wrote: Hi, I actually do have this and have used this for a couple of years when I¡¯m doing stitch work while traveling. Can¡¯t beat the price and it¡¯s convenient and portable. There are several different magnification lenses to choose from.?
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Re: Has anyone tried this item? If yes, is it helpful for people with NAION? I am skeptical.
Hi, I actually do have this and have used this for a couple of years when I¡¯m doing stitch work while traveling. Can¡¯t beat the price and it¡¯s convenient and portable. There are several different magnification lenses to choose from.?
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On Mar 14, 2025, at 12:39?AM, Marc Gold via groups.io <marcgold@...> wrote:
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Has anyone tried this item? If yes, is it helpful for people with NAION? I am skeptical.
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Re: Semaglutide and NAION
Thanks for finding and posting this. ?Quite often, especially in medicine, ¡°the sky is falling¡± reaction is also a knee jerk reaction. ?His comments about antibodies is particularly interesting as I¡¯ve never heard that ¡°association¡± before and it is ?an interesting idea.?
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Re: digital magnifiers for visually impaired
Chiarina Blake,
Specifically which magnifier from Vision Australia did you order?
Thanks,
Marc
On Sun, Mar 9, 2025 at 11:55?PM Chiarina Blake via <jc.blake2= [email protected]> wrote: Thank you so much I will be getting the hands free magnifier from Vision Australia. Very useful. Can I ask if any one uses Kindle to read books with? If so, which one??
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L[NAION] best phones, , browsers drugs?
1) Anyone have suggestions for the best phones for the visually impaired? 2) Anyone have suggestions for the best internet browsers?
3) Anyone have ?experiences with: ?Pentoxifylline (Trental) Citicoline? Niacinmide B-3 (high doses)urrently experiencing NAION in 2nd eye and appreciate ?your experience and suggestions.
Thank you. Debra B Debrownstein@gmail,com
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Re: digital magnifiers for visually impaired
Thank you for you help Gary and Pamela x?
On Tue, 11 Mar 2025 at 12:41?am, Pamela Chadick via <apchadick88= [email protected]> wrote: Thank you so much for these suggestions! I'm looking into them - so encouraging. I read on my ipad and adjust the lighting and font, but I know many who use a Kindle Fire. It is most compatible with the library apps - hoopla, cloudLibrary and Libby. Also, there are free audible and large print programs in libraries. .
On Mon, Mar 10, 2025 at 1:55?AM Chiarina Blake via <jc.blake2= [email protected]> wrote: Thank you so much I will be getting the hands free magnifier from Vision Australia. Very useful. Can I ask if any one uses Kindle to read books with? If so, which one??
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Re: digital magnifiers for visually impaired
Thank you so much for these suggestions! I'm looking into them - so encouraging. I read on my ipad and adjust the lighting and font, but I know many who use a Kindle Fire. It is most compatible with the library apps - hoopla, cloudLibrary and Libby. Also, there are free audible and large print programs in libraries. .
On Mon, Mar 10, 2025 at 1:55?AM Chiarina Blake via <jc.blake2= [email protected]> wrote: Thank you so much I will be getting the hands free magnifier from Vision Australia. Very useful. Can I ask if any one uses Kindle to read books with? If so, which one??
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ReeRee
GaryGBrown